在精神分裂症的第一发作中,口服与长效注射抗精神病药:一项为期12周的干预性研究
Ramandeep Kaur1, Ajeet Sidana1, Nidhi Malhotra1
1Department of Psychiatry, Government Medical College and Hospital, Chandigarh, India.
Indian journal of psychiatry
|June 16, 2023
概括
长效注射性 (LAI) 利在第一发精神分裂症 (FES) 中显示出与口服利相似的治疗反应. LAI haloperidol提供了更好的坚持和生活质量,副作用更少.
科学领域:
- 精神病学是一个精神病学.
- 药理学 药理学是指药理学的学科.
- 临床神经科学 临床神经科学
背景情况:
- 长效注射 (LAI) 抗精神病药物在第一发精神分裂症 (FES) 中未得到充分利用.
- 临床治疗剂通常只适用于缺乏服药能力或慢性疾病的患者.
- 目前的使用模式并不能充分利用LAI对早期干预的好处.
研究的目的:
- 为了比较LAI哈洛佩里多尔与口服哈洛佩里多尔在FES治疗先前的患者中的疗效和耐受性.
- 评估 LAI 利对早期精神分裂症患者的坚持和生活质量的影响.
主要方法:
- 一项随机对照试验,涉及72名以前未接受过治疗的FES患者.
- 使用正负综合征量表 (PANSS) 评估精神病理学.
- 在12周内使用WHOQOL-BREF尺度对生活质量 (QOL) 的评估.
主要成果:
- 口服和LAI两种类型的利都显著降低了PANSS得分,并改善了QOL (P=0.0001).
- 在LAI组表现出明显更好的坚持和QOL (P=0.023).
- 在第二周,与口服组相比,在LAI组观察到的副作用较少.
结论:
- LAI皮醇是一种可行的,有效的替代口服皮醇用于FES.
- LAI haloperidol在坚持,生活质量和早期耐受性方面具有优势.
- 在FES中增加LAI的使用可能会改善长期结果.
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