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加拿大侵袭性脑膜炎球菌病的流行病学,2012-2019年

Myriam Saboui¹, Raymond Sw Tsang², Robert MacTavish¹

¹Centre for Immunisation and Respiratory Infectious Diseases, Public Health Agency of Canada, Ottawa, ON.

Canada communicable disease report = Releve des maladies transmissibles au Canada

|June 16, 2023

概括

侵入性脑膜炎球菌病 (IMD) 在加拿大仍然是一个罕见但严重的威胁,主要影响年幼儿童. 血清组B是主要原因,与ST-11 CC相关的血清组W菌株的增加令人担忧.

科学领域:

公共卫生公共卫生
传染性疾病传染性疾病
疫苗学疫苗学疫苗学

背景情况:

自2002年以来,加拿大实施了各种脑膜炎球菌疫苗接种计划.
这些计划使用单价 (血清组C) 和四价 (A,C,Y,W) 联合疫苗.
脑膜炎球菌疫苗也用于疫情应对,包括血清组B疫苗.

研究的目的:

描述加拿大侵入性脑膜炎球菌病 (IMD) 的流行病学.
分析2012年至2019年之间的IMD趋势.
识别关键血清组及其相关的克隆复合体.

主要方法:

从国家增强的IMD监控系统 (2012-2019) 中收集的数据.
由国家微生物学实验室确认和描述的脑膜炎球菌分离物.
分析包括血清组,表型和克隆复合体识别.

主要成果:

从2012年到2019年,共有983例IMD病例被报告.
根据年龄调整的IMD总发病率为每10万人口0.34例.
婴儿 (<1岁) 的发病率最高 (3.6/100,000);B血清组是最常见的 (0.17/100,000).
血清组W病例增加,由ST-11 CC驱动,取代了ST-22 CC.

结论:

侵袭性脑膜炎球菌病在加拿大罕见但严重,主要影响年轻人.
血清组B仍然是IMD的主要原因.
血清组W,特别是ST-11 CC,在未接种疫苗的人群中越来越令人担忧.

关键词:

加拿大加拿大加拿大加拿大加拿大加拿大流行病学流行病学侵袭性脑膜炎球菌疾病这是一种脑膜炎球菌.

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