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将儿童QL^TM 4.0映射到CHU-9D上:在中国的功能性消化不良患者中进行的横截面研究

Qiqi Wang¹, Chuchuan Wan¹, Maozhen Li¹

¹The Research Center of National Drug Policy & Ecosystem, China Pharmaceutical University, Nanjing, China.

Frontiers in public health

|June 16, 2023

概括

一个新的映射算法准确地将儿科生活质量库存 (Peds QL 4.0) 评分转换为功能性消化不良儿童的儿童健康实用 9D (CHU-9D) 值.

科学领域:

儿科健康研究成果研究成果
卫生经济学卫生经济学
心理测量心理测量心理测量

背景情况:

功能性消化不良 (FD) 严重影响儿童的生活质量.
准确的健康实用测量对于健康技术评估 (HTA) 至关重要.
现有的数据通常依赖于诸如儿科生活质量库存TM 4.0 (Peds QL 4.0) 等仪器,而不是直接提供实用值.

研究的目的:

开发和验证一个映射算法,将Peds QL 4.0分数与儿童健康实用程序9D (CHU-9D) 值联系起来.
为了使儿童群体中的Peds QL 4.0数据能够估计健康实用值.
支持HTA在只有Peds QL 4.0数据可用的研究中.

主要方法:

利用了2152名被诊断患有FD的中国儿童和青少年的截面数据.
采用了六种回归模型,包括托比特回归,用于直接和响应映射.
使用诸如平均绝对误差 (MAE),根平均平方误差 (RMSE) 和一致相关系数 (CCC) 等指标评估模型性能.

主要成果:

托比特回归模型,结合Peds QL 4.0项目分数,性别和年龄,显示出最高的预测准确度.
该研究确定了独立变量的最佳组合,以便准确地绘制地图.
性能指标证实了开发的映射算法的可靠性.

结论:

一个经过验证的映射算法有效地将Peds QL 4.0数据转换为CHU-9D健康实用值.
这种算法在临床研究中对HTA有价值,仅限于Peds QL 4.0数据收集.
促进了儿科FD研究中更全面的经济评估.

关键词:

在CHU-9D中使用.儿童 QL 4.0 儿童 QL 4.0 儿童功能性消化不良症功能性消化不良症健康实用价值的健康实用价值.绘制地图,绘制地图.

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