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维生素D状况和动障碍:观察性研究的系统审查和元分析

Lin Xiaoxia¹, Jiang Jilong¹, Chen Xianrui²

¹Department of Pediatrics, Fujian Medical University Union Hospital, Fuzhou, China.

Frontiers in pediatrics

|June 16, 2023

概括

患有滴答障碍 (TD) 的儿童的维生素D水平比健康儿童低. 需要进一步的研究来证实TD亚型,如图雷特综合征 (TS) 的发现.

科学领域:

神经科学是一个神经科学.
儿科儿科儿科
营养科学营养科学

背景情况:

疾病 (TD) 是影响儿童的神经发育的常见疾病.
TD包括过渡性滴滴障碍 (TTD),慢性运动或声部滴滴障碍 (CTD) 和图雷特综合征 (TS).
儿童群体中维生素D水平和TD之间的关系需要进一步研究.

研究的目的:

评估维生素D水平与儿童动障碍之间的临床关联.
为了比较被诊断患有TD的儿童和健康对照组 (HC) 之间的血清维生素D水平.
分析不同TD亚型 (TTD,CTD,TS) 的维生素D水平.

主要方法:

对观察性研究进行了系统审查和元分析.
在2022年6月之前搜索的主要数据库 (CNKI,万芳,VIP,Cochrane,PubMed,Embase)
包括13项比较TD与HC儿童血清维生素D水平的研究,分析TD亚型.

主要成果:

与HC相比,患有TD的儿童的血清维生素D水平明显较低 (MD = -6.64,P < 0.001).
在TTD和CTD之间,或在CTD和TS组之间,没有发现维生素D水平的显著差异.
在TTD和TS组之间观察到显著差异 (MD = 5.24,P = 0.02).
与HC相比,TD组的男性比例较高 (OR = 1.48,P = 0.02).

结论:

分析表明,与健康儿童相比,TD儿童的维生素D水平较低.
亚组分析没有显示TD亚型之间的维生素D水平有显著差异.
由于研究的局限性,建议进行高质量的,大规模的多中心研究来验证这些发现.

关键词:

孩子们的孩子们的孩子们的孩子们.这是一个元分析.系统性审查系统性审查图奇障碍图奇障碍图奇障碍维生素D是维生素D的重要组成部分.

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