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多维未来主义的方法来解决COVID-19之外的流行病
Shifa Bushra Kotwal1, Nidhi Orekondey1, Gargi Prasad Saradadevi1
1Department of Biological Sciences, BITS Pilani, Hyderabad Campus, Telangana 500078, India.
Heliyon
|June 16, 2023
概括
本综述探讨了用于快速病毒诊断和治疗未来流行病的新型分子工具. 它强调了非PCR检测方法,芯片上的实验室设备,以及基于植物和疫苗重新定位的创新策略.
科学领域:
- 分子生物学分子生物学
- 病毒学 病毒学
- 生物技术是生物技术.
- 流行病的准备情况.
背景情况:
- 由于COVID-19大流行,全球死亡率和发病率非常高.
- 有效的流行病管理需要先进的诊断和治疗方法.
- 现有的诊断和治疗策略在速度,成本和可扩展性方面存在局限性.
研究的目的:
- 审查病毒诊断和治疗的分子工具的最新进展.
- 提出用于病毒检测的新,快速和具有成本效益的方法.
- 讨论未来的流行病准备和疾病管理的创新战略.
主要方法:
- 审查当前和新兴的病毒诊断技术.
- 关于新型非PCR基核酸检测方法 (RNA模仿,基于核酶) 的建议.
- 探索与网络物理系统集成的实验室芯片 (LoC) 设备.
- 讨论尚未探索的抗病毒策略 ( рибо酶,植物基平台).
- 对疫苗重新使用的调查,特别是Bacillus Calmette-Guérin (BCG).
主要成果:
- 鉴定了当前病毒诊断和治疗方法的局限性.
- 为快速,单步病毒核酸检测提出了新的非PCR方法.
- 突出了小型化实验室芯片设备的潜力,用于集成诊断.
- 展示了可扩展的抗病毒生产和交付的基于植物的平台的进步.
- 强调了重新利用现有疫苗的潜力,比如BCG,用于新的应用.
结论:
- 新型分子工具为快速病毒诊断和有效治疗提供了有希望的途径.
- 创新的方法,如非PCR检测,LoC设备和基于植物的平台,可以增强疫情应对.
- 重新利用现有疫苗为广泛的保护和未来的流行病准备提供了一个可行的战略.
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