结直肠癌中CDX2表达损失和不匹配修复缺陷的潜在预测因素
Ivan Vlahović1, Jasmina Rajc2, Ivan Švagelj3
1Department of Abdominal Surgery, Clinical Hospital Center Osijek, Faculty of Medicine, University of Osijek, Osijek, Croatia.
Pathology oncology research : POR
|June 16, 2023
概括
结直肠癌中CDX2表达的丧失与不匹配修复缺陷 (dMMR) 有关,特别是MLH1/PMS2缺陷. 瘤差异化也预测了CDX2损失,这表明CDX2损失是dMMR的潜在预测因素.
科学领域:
- 在瘤学瘤学.
- 分子病理学分子病理学
- 胃肠病学 胃肠病学
背景情况:
- CDX2表达损失是结肠直肠癌 (CRC) 中不匹配修复缺陷 (dMMR) 的已知标志物.
- 有限的研究已经探索了CDX2损失和个体不匹配修复 (MMR) 基因 (MLH1,MSH2,MSH6,PMS2) 之间的特定相关性.
研究的目的:
- 调查CDX2表达损失与结直肠癌中的特定MMR基因缺陷之间的关联.
- 在CRC中确定CDX2表达损失和dMMR的预测因子.
- 评估CDX2表达损失作为dMMR的潜在预测因素.
主要方法:
- 对336例结直肠癌 (CRC) 病例的回顾性分析.
- 对CDX2,MLH1,MSH2,MSH6和PMS2表达的组织病理学数据和免疫组织化学分析的收集.
- 统计分析以确定关联并构建回归模型.
主要成果:
- 在5.9%的CRC中观察到CDX2表达损失,并与上升的结肠瘤,粘膜腺癌和差异化癌症相关.
- 在13.1%的CRC中发现了不匹配修复缺陷 (dMMR).
- 在CDX2表达损失和MLH1/PMS2异构体缺乏之间发现了显著的关联.
- 瘤差异化和MLH1/PMS2缺乏被确定为CDX2表达损失的独立预测因素.
- CDX2表达损失和上升的结肠位置是dMMR的预测因素,而直肠癌是负面预测因素.
结论:
- CDX2表达损失与结直肠癌中的MLH1和PMS2缺乏有显著的关联.
- 瘤差异化和MLH1/PMS2异构体缺乏是CDX2表达丧失的独立预测因素.
- CDX2表达损失可能成为CRC中dMMR的预测因素,需要进一步调查.
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