对FAP进行多因素分析,以调节胃肠道癌症的进展
Jialing Cai1, Depeng Yang1, Handi Sun1
1School of Life Science and Technology, Harbin Institute of Technology, Harbin, Heilongjiang, China.
Frontiers in immunology
|June 16, 2023
概括
纤维细胞激活蛋白 (FAP) 在胃肠道癌症中被上调,促进瘤细胞的运动和M2巨细胞的两极分化. 这项研究揭示了FAP.
科学领域:
- 在瘤学瘤学.
- 癌症生物学 癌症生物学
- 免疫学 免疫学 免疫学
背景情况:
- 纤维细胞激活蛋白 (FAP) 是纤维细胞和癌细胞组织中高调的血清蛋白酶.
- FAP在胃肠道 (GI) 癌症中的作用尚未完全理解,尽管它在癌症进展中的重要性已知.
- 对于FAP在肠道恶性瘤中的功能,存在有限的多因素分析.
研究的目的:
- 综合评估FAP在肠道癌症中的致癌潜力.
- 分析FAP表达与患者结果之间的相关性,以及瘤免疫学.
- 用肝癌作为模型,实验验验证FAP在肠道癌症中的促瘤和免疫调节作用.
主要方法:
- 利用TCGA,CPTAC,scTIME门户网站和HPA的数据集进行生物信息分析.
- 在肝,结肠,胰腺和胃癌中研究了FAP表达和与结果和免疫透的相关性.
- 在LX2细胞中进行过度表达FAP的体外实验,以评估对肠道癌细胞和巨细胞的影响.
主要成果:
- 在LIHC,COAD,PAAD和STAD中丰富地表达FAP,与细胞外矩阵组织相关.
- 高FAP表达与这些肠胃癌中M2巨细胞透率的增加有关.
- 在LX2细胞中过度表达FAP促进了肠道癌细胞的运动性和M2巨细胞的极化和入侵.
结论:
- 在肠道癌中,FAP在纤维细胞中显著上调.
- FAP有助于瘤细胞运动,巨细胞透和M2极化.
- 这项研究强调了FAP在推动胃肠道癌症进展中的多因素作用.
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