剧烈的运动会在患有前列腺癌的男性中诱导不同的定量和表型T细胞概况
Erik D Hanson1,2,3,4, Samy Sakkal4, Lauren C Bates-Fraser1,2,3
1Department of Exercise & Sport Science, University of North Carolina, Chapel Hill, NC, United States.
Frontiers in sports and active living
|June 16, 2023
概括
前列腺癌幸存者对急性运动表现出正常的T细胞反应,与健康对照人群相比. 基剥夺疗法 (ADT) 可能会影响T细胞成熟,但其功能影响需要进一步研究.
科学领域:
- 免疫学 免疫学 免疫学
- 运动生理学 运动生理学
- 在瘤学瘤学.
背景情况:
- 降低丸激素水平可能会影响T细胞功能.
- 众所周知,运动可以动员免疫细胞,但它对前列腺癌幸存者的T细胞的影响,特别是那些接受雄激素剥夺疗法 (ADT) 的人,尚不清楚.
- 研究前列腺癌幸存者对急性运动的T细胞反应对于了解癌症恢复期间的免疫功能至关重要.
研究的目的:
- 为了比较常规和非常规T细胞 (UTC) 对前列腺癌幸存者 (有或没有ADT) 与健康对照者的急性运动的反应.
- 评估运动后T细胞数量,频率和细胞内孔素水平的变化.
- 确定ADT对T细胞特征及其对运动反应的影响.
主要方法:
- 接受ADT的前列腺癌幸存者,没有ADT的前列腺癌幸存者和健康的对照组进行了间歇性自行车运动.
- 免疫细胞群和细胞内孔素在运动前,运动后2小时,运动后24小时进行测量.
- 流细胞计用于分析T细胞子集和穿孔素表达.
主要成果:
- 在所有组中,T细胞数量在运动后立即显著增加.
- 虽然T细胞频率出现过渡性下降,但在总体T细胞或非传统T细胞 (UTC) 对运动反应方面没有显著的群体差异.
- 抗雄激素剥夺疗法 (ADT) 与较低的CD8+T细胞成熟度 (CD57+) 相关,但增加了CD8+孔素表达,表明潜在的变异表型.
结论:
- 包括那些接受ADT的前列腺癌幸存者,表现出与健康对照者相似的T细胞和UTC对急性炼的反应.
- ADT与较不成熟的CD8+ T细胞表型有关,其特征是CD57+表达率较低.
- 在ADT患者中,孔素水平升高可能会调节这些效应,尽管功能意义仍有待阐明.
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