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P V Datsenko¹, T M Kobyletskaya¹, A S Chuguev¹

¹National Research Medical Center of Radiology, Moscow, Russia.

Zhurnal voprosy neirokhirurgii imeni N. N. Burdenko

|June 16, 2023

概括

手术和放射治疗之间的早期质母细胞瘤进展显著影响了生存率. 经历瘤生长的患者的整体存活率较短,突出显示需要不同的预后组.

科学领域:

神经瘤学神经瘤学
辐射瘤学辐射瘤学
手术瘤学手术瘤学

背景情况:

质母细胞瘤 (4级) 是一种具有攻击性的脑瘤.
治疗包括手术,然后进行放射治疗.
治疗阶段之间的瘤进展可能会影响结果.

研究的目的:

分析手术和放射治疗之间质母细胞瘤生长对患者存活率的影响.
为了确定早期瘤进展的预测因素.

主要方法:

分析了140名质母细胞瘤患者.
治疗包括用2Gy或3Gy分数对对建模.
在微手术和放射治疗之间评估了早期进展.

主要成果:

60名患者 (43%) 呈现出早期进展,中位数为1.1个月.
早期进展的预测因素包括切除质量,大的残留瘤和没有MGMT甲基化.
与没有 (33.41个月) 患者相比,早期进展的患者的平均整体存活时间明显较短 (16.03个月).
在没有早期进展的患者中,两年生存率高于3 Gy分离 (65%) 与2 Gy (50%).

结论:

近一半的质母细胞瘤患者在手术和放射治疗之间经历了早期进展.
早期进展是整体存活时间的显著负面预后因素.
根据早期进展状态,患者应分为不同的预后组.

关键词:

这是早期进展的早期进展.质母细胞瘤 (glioblastoma) 是一种辐射疗法辐射疗法

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