通过Pt(IV) 功能化二氧化纳米结构的氧化双开关癌症治疗学
Beatriz Brito1,2,3, Maria Rosaria Ruggiero1, Thomas W Price1
1Department of Imaging Chemistry and Biology, School of Biomedical Engineering and Imaging Sciences, King's College London, Strand, WC2R 2LS London, UK. graeme.stasiuk@kcl.ac.uk.
Nanoscale
|June 16, 2023
概括
装有Pt(IV) 前药物的二氧化纳米结构显示出作为对TME反应敏捷的治疗药物具有前途. 这些新型纳米粒子有效治疗瘤,并为癌症治疗提供增强的MRI对比度.
科学领域:
- 生物医学工程 生物医学工程
- 纳米技术纳米技术
- 材料科学 材料科学 材料科学
背景情况:
- 瘤微环境 (TME) 响应平台对于向癌症治疗至关重要.
- 基于二氧化 (MnO2) 的纳米结构为对TME反应的药物递送提供了潜力.
- 开发结合治疗和诊断的有效治疗术是癌症研究的一个关键目标.
研究的目的:
- 为了合成和评估MnO2纳米结构与Pt(IV) 前药功能为TME-响应性癌症治疗.
- 评估这些新型纳米结构的治疗疗效和磁共振 (MR) 成像能力.
- 研究MnO2-Pt(IV) 纳米颗粒的氧化还原反应行为,以改善癌症治疗和诊断.
主要方法:
- 一合成MnO2纳米结构,其中包含Pt(IV) 前药物.
- 在2D和3DA549细胞模型中评估细胞毒性.
- 评估磁共振 (MR) 对比增强在减少剂 (例如,酸) 的反应 in vitro 和 in vivo.
- 在A549瘤携带小鼠体内MRI实验.
主要成果:
- 在3D细胞模型中,MnO2-Pt(IV) 纳米结构表现出与西斯胺可比的细胞毒性.
- 观察到显著的关闭/启动磁共振 (MR) 对比切换,在减少时,纵向放松率 (r1) 增加了136倍.
- 在体内MRI显示,在小鼠的内注射后,T1信号强烈且持续增强.
- 在细胞模型和体内实验中证实了对氧化反应反应的行为.
结论:
- MnO2-Pt(IV) 纳米颗粒代表了癌症治疗的有前途的氧化还原反应性治疗药物.
- 这些纳米结构为化学疗法和MRI成像提供了双重功能.
- 这些治疗药物对TME的响应性增强了它们在向癌症治疗和监测方面的潜力.
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