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响应较差的人的早期或延迟反应:它是否会对周期结果产生影响?
Inci Kahyaoglu1, Elif Ceren Tutkun Kilinc2, Cavidan Gulerman3
1Department of Reproductive Endocrinology, Etlik Zubeyde Hanim Women's Health Hospital, University of Health Sciences, Ankara, Turkey.
这项研究发现,较短的卵巢刺激持续时间不会对卵巢反应不良 (POR) 患者的怀孕率产生负面影响. 对于POR患者卵细胞成熟的最佳刺激长度尚不清楚,但更短的周期是可行的.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 在体外受精 (IVF)
- 卵巢刺激协议 卵巢刺激协议
背景情况:
- 根据博洛尼亚标准定义,在卵巢反应不良 (POR) 的患者中,卵巢刺激的最佳持续时间来实现卵细胞成熟,目前的文献中尚未得到很好的确立.
- 卵巢反应显著影响IVF周期期间所需的整体刺激时间.
研究的目的:
- 调查卵巢刺激的较短持续时间 (<9天) 是否会影响被诊断为卵巢反应不良 (POR) 的患者体外受精周期的结果.
主要方法:
- 一个回顾性分析267个试管婴儿周期的患者满足波隆纳标准的POR.
- 患者被分为两组:A组 (刺激时间<9天) 和B组 (刺激时间≥9天).
- 两个组之间的参数比较,包括 antral 毛囊数量,血清雌激醇水平,淋巴激素剂量和卵细胞检索数量.
主要成果:
- 与A组相比,B组 (更长时间的刺激) 的 antral毛囊数量,hCG一天的血清雌激醇和总淋巴激素剂量显著增加.
- 在B组中,总和成熟卵细胞的数量也显著增加.
- 尽管卵细胞产量有差异,但在较短 (<9天) 和较长 (≥9天) 的刺激组之间没有观察到统计学上显著的怀孕率差异.
结论:
- 较短的卵巢刺激时间 (<9天) 似乎对卵巢反应不良 (POR) 患者的试管婴儿周期结果没有有害影响.
- 这些发现表明,对于POR患者来说,个性化刺激方案可能是可行的,而不会影响怀孕的成功.
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