基于通过数字光处理制造的合成聚电解质水凝制造的3D打印和刺激响应药物递送系统
Sonja Vaupel1,2, Robert Mau3,4, Selin Kara1
1Institute of Technical Chemistry, Leibniz University Hannover, Callinstraße 5, 30167 Hannover, Germany. johanna.meyer@iftc.uni-hannover.de.
Journal of materials chemistry. B
|June 16, 2023
概括
这项研究引入了新的3D打印水凝,用于先进的药物输送. 这些柔性和可膨胀的材料展示了受控的药物释放,并允许创建复杂的生物医学设备原型.
科学领域:
- 材料科学 材料科学 材料科学
- 生物医学工程 生物医学工程
- 聚合物化学 聚合物化学
背景情况:
- 水凝是超吸收性聚合物,具有诸如生物相容性和胀等多功能性质.
- 传统的制造方法限制了复杂的水凝结构的创建.
- 增材制造,特别是3D打印,可以精确制造复杂的设计.
研究的目的:
- 开发使用增材制造用于生物医学应用的新型合成水凝.
- 为了研究这些3D打印的水凝的胀,机械和药物释放特性.
- 展示创建复杂,可定制的药物输送系统和医疗器械原型的潜力.
主要方法:
- 使用数字光处理 (DLP) 3D打印,层高度为100微米.
- 合成的水凝使用[2-烯氧乙烯]三甲基化物 (AETMA) 和聚乙烯糖醇) - 二烯酸盐 (PEGDA).
- 嵌入式酸 (ASA) 作为一种模型药物,用于研究各种介质中的释放动力学.
主要成果:
- 达到高胀度 (q∞m,t ∼ 12) 和出色的伸展性 (εmax ∼ 300%).
- 展示了对刺激有反应的药物释放行为,表明离子交换特性.
- 成功3D打印复杂的空心几何形状,包括一个原型植入物.
结论:
- 开发了一种灵活,可膨胀和释放药物的3D打印水凝材料.
- 突出了DLP3D打印在制造先进,可定制的生物医学设备方面的潜力.
- 展示了这些水凝在触发和顺序药物递送应用中的实用性.
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