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Updated: Jul 26, 2025

Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog
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Fluorescence-based Monitoring of PAD4 Activity via a Pro-fluorescence Substrate Analog

Published on: November 5, 2014

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更新了PARP蛋白家族的蛋白质域注释,为生物功能提供了新的了解

Marcin J Suskiewicz1, Deeksha Munnur2, Øyvind Strømland2,3

  • 1Centre de Biophysique Moléculaire, CNRS UPR 4301, Orléans, France.

Nucleic acids research
|June 16, 2023
PubMed
概括

这项研究使用AlphaFold2来建模人类的Poly ((ADP-ribose) 聚合酶 (PARP) 蛋白质,揭示了它们的结构,功能和与RNA和类似于ubiquitin的修饰物的相互作用的新见解.

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Conservation of Protein Domains Over Different Proteins02:26

Conservation of Protein Domains Over Different Proteins

Protein domains are small structurally independent units that are part of a single amino acid chain.  Although these domains are often structurally independent, they may rely on synergistic effects to perform their functions as part of a larger protein. Protein domains may be conserved within the same organism, as well as across different organisms.
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Groups of proteins may form a complex where each protein in this complex has a different role in the overall execution of the complex’s function. Often some of the proteins in the complex can be replaced by a closely related variant to give a complex that contains many of the same components yet is functionally distinct.
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