自然产品作用于对抗S. 黄金色通过膜和细胞壁的破坏
1Department of Natural Products, Chemical Sciences, National Institute of Pharmaceutical Education and Research-Hyderabad, Hyderabad, Balanagar, 500037, India. gautam.kumar2@niperhyd.ac.in.
Natural product reports
|June 16, 2023
概括
天然产品提供了对抗多药耐药黄金葡萄球菌感染的有希望的策略. 这项研究审查了针对细菌膜及其生物合成酶的药物,这些药物对于开发新抗生素至关重要.
科学领域:
- 微生物学 微生物学
- 药理学 药理学是指药理学的学科.
- 自然产品 化学 化学
背景情况:
- 黄金葡萄球菌 (S. aureus) 导致严重的社区和医院感染.
- 滥用抗生素加速了多抗药性病原体的出现.
- 细菌细胞壁合成酶是抗生素的主要点.
研究的目的:
- 总结一下针对细菌膜的天然产品的最新进展.
- 审查抑制膜成分和生物合成酶的药物.
- 讨论既定和新型药物的作用机制.
主要方法:
- 对2015-2022年研究的文献综述.
- 对影响细菌膜完整性的自然产品的分析.
- 检查针对嵌入膜蛋白和生物合成酶的药物.
主要成果:
- 天然产品在对抗黄金色杆菌方面显示出显著的潜力.
- 有几种药物直接抑制细菌膜的功能.
- 机制包括准膜组件和必需酶.
结论:
- 自然产品对于发现新型抗菌剂至关重要.
- 针对细菌膜及其生物合成提供了一个有希望的战略.
- 对天然产品机制的进一步研究可以帮助抗生素的开发.
相关概念视频
Antimicrobial Proteins
1.1K
Antimicrobial proteins are important components of the immune system. They aid the body in combating pathogens by either killing them directly or hindering their replication processes. Four main types of antimicrobial substances are interferons, the complement system, iron-binding proteins, and antimicrobial proteins.
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
Interferons
Interferons (IFNs) are proteins produced by lymphocytes, macrophages, and fibroblasts infected with viruses. While IFNs cannot prevent viruses from entering and...
1.1K
Surface Membrane Barriers
1.2K
The skin and mucous membranes serve as the primary line of defense against pathogens by providing both physical and chemical protection. These barriers are essential in preventing the entry and establishment of microbes, thereby maintaining the integrity of the host.
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
The outer layer of the skin, the epidermis, is a robust barrier comprising layers of closely packed keratinized cells. This dense arrangement prevents microbes from penetrating the body. The periodic shedding of epidermal cells...
1.2K
Biological Methods for Microbial Control
144
Biological agents offer an effective means of controlling microbial growth by leveraging natural processes like predation, competition, and the secretion of antimicrobial substances.Predatory bacteria such as Bdellovibrio species target and kill pathogens like Salmonella and E. coli. They are widely used in poultry farms to control infections. Myxococcus species help combat plant-pathogenic fungi. These naturally occurring predators serve as eco-friendly alternatives to chemical pesticides and...
144
Chemical Agents for Microbial Control
141
Chemicals play important roles in controlling microbial growth by targeting microbial structures and functions as sanitizers, antiseptics, disinfectants, and sterilants.Alcohols are commonly used sanitizers, effectively disrupting lipid membranes, which compromises cell integrity. They are also used as antiseptics and disinfectants due to their rapid action and versatility.Phenols and their derivatives phenolics , known for denaturing proteins and disrupting cell membranes, are particularly...
141
Defense Against Bacterial Pathogens
1.5K
The human immune system is a complex network of cells, tissues, and organs that work together to defend the body against bacterial infections. It consists of various immune cells, each playing a specific role in the defense mechanism.
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
1.5K
Antimicrobial Effectiveness
98
The effectiveness of antimicrobial agents depends on various factors influencing their ability to eliminate microbial populations. Larger microbial populations require more time for complete eradication, emphasizing the importance of population size analysis when evaluating antimicrobial efficacy.Microbial resistance to antimicrobial agents varies significantly. Highly resilient microorganisms include endospores, gram-negative bacteria, and non-enveloped viruses, while prions are exceptionally...
98


