大型整形外科手术中的骨循环概况和肌肉状况:一个案例系列
Vanna Bottai1, Gabriele Filoni2, Lorenzo Andreani3
1Ortopedia e Traumatologia Universitaria II - Universita' di Pisa - Azienda Ospedaliera Universitaria Pisana. vannabottai@yahoo.it.
Acta bio-medica : Atenei Parmensis
|June 16, 2023
概括
主要的骨科手术患者经常患有局部性肉症 (肌肉损失) 和骨质疏松症,独立于维生素D水平. 这表明需要综合治疗方法来改善手术结果.
科学领域:
- 整形外科 整形外科 整形外科
- 肌肉骨健康 肌肉骨健康
- 代谢性骨疾病 代谢性骨疾病
背景情况:
- 石症,骨肌肉质量的损失,与衰老和维生素D缺乏有关,增加了跌倒和骨折的风险.
- 骨类骨质疏松症描述了类骨质疏松症和骨质疏松症的联合存在.
- 大型骨科手术后不使用可导致局部肌肉和骨问题.
研究的目的:
- 分析接受重大骨科手术的患者的骨质代谢概况和肌肉状况.
- 为了确定本患者群中与不使用相关的局部骨骨状况的发生率.
主要方法:
- 评估了19名接受重大骨科手术的患者 (15-85岁),其中包括9例瘤病例.
- 通过血液检查评估和代谢.
- 进行了手术期间的肌肉活检 (受影响的肢体和对侧肢体) 和密度测量研究 (3例).
主要成果:
- 百分之百的患者仅在受影响的肢体中显示了sarcopenic模式.
- 66%的密度测量研究显示受影响四肢的局部区域性骨质疏松症与逆侧相比.
- 观察到的代谢异常:维生素D下降 (5),低血 (7),PTH升高 (5),ALP升高 (4).
结论:
- 在这个样本中,受影响四肢的局部性肉类和骨质疏松症似乎独立于维生素D缺乏.
- 这些疾病可能具有与一般化骨髓瘤症分开的明显的病原遗传机制.
- 综合的外科,药物和康复策略对于优化骨科手术的结果至关重要.
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