在重症监护室的共同感染. 随着COVID-19大流行,有没有什么变化?
Federica Romanelli1, Stefania Stolfa2, Luigi Ronga3
1a:1:{s:5:"en_US";s:115:"1Section of Microbiology, Interdisciplinary Department of Medicine, University of Bari "Aldo Moro", Bari, Italy";}. federica.romanelli@policlinico.ba.it.
Acta bio-medica : Atenei Parmensis
|June 16, 2023
概括
这项研究将COVID-19患者的细菌和真菌共同感染与大流行前重症监护室 (ICU) 患者的共同感染进行了比较. 研究结果显示,在COVID-19患者中,特定的病原体,如Acinetobacter baumannii更为普遍,指导经验性治疗选择.
科学领域:
- 医学微生物学 医学微生物学
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
背景情况:
- 新冠肺炎2019 (COVID-19) 疫情引发了人们对二次细菌和真菌感染的担忧.
- 这些共同感染可以显著增加严重急性呼吸系统综合征冠状病毒2 (SARS-CoV-2) 患者的疾病严重程度和死亡率.
- 了解共感染模式的变化对于有效的患者管理和实证治疗策略至关重要.
研究的目的:
- 评估COVID-19患者的细菌和真菌共同感染的发生率和类型,这些患者被送往ICU.
- 为了将这些同时感染率与在COVID-19前的时代被送往重症监护室的患者的同时感染率进行比较.
- 为了确定疫情是否改变了ICU设置中的过度感染的流行率.
主要方法:
- 从1905名患者的临床样本 (血液培养物,尿液,气管支气管吸附物) 的分析.
- 在大流行期间,为SARS-CoV-2患者建立了专门的重症监护室 (ICU).
- 在COVID-19患者和非COVID-19患者之间比较微生物分离的流行率.从COVID-19前的时代.
主要成果:
- 在COVID-19和非COVID-19患者之间观察到病原体流行率的统计学上显著差异.
- 特定的病原体,如Acinetobacter baumannii复合体,Aspergillus fumigatus,Escherichia coli,Haemophilus influenzae和Serratia marcescens在呼吸道样本中显示出不同的患病率.
- 尿液中的Candida albicans和血液培养中的Acinetobacter baumannii复合体,Enterococcus faecalis和Enterococcus faecium也存在显著差异.
结论:
- 虽然孤立的生物在与医疗相关的感染中很常见,但COVID-19患者表现出Acinetobacter baumannii,Stenotrophomonas maltophilia和Aspergillus spp.的特别流行. 在呼吸道中.
- 在COVID-19患者的尿样中,Candida albicans的显著增加被注意到.
- 在COVID-19患者的血液中感染的感染主要与Acinetobacter baumannii,Enterococcus faecalis和Enterococcus faecium有关.
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