![Quantitative SERS Detection of Uric Acid via Formation of Precise Plasmonic Nanojunctions within Aggregates of Gold Nanoparticles and Cucurbit[n]uril](/_next/image?url=https%3A%2F%2Fcloudfront.jove.com%2FCDNSource%2Fteasers%2F61682.jpg&w=3840&q=50)
通过超分子氨酸-海米库尔比特[8]uril-Functionalized重力测量传感器进行体识别
Gabriele Magna1, Marko Šakarašvili2, Manuela Stefanelli1
1Department of Chemical Science and Technologies, University of Rome Tor Vergata, Via Della Ricerca Scientifica 1, 00133 Rome, Italy.
ACS applied materials & interfaces
|June 16, 2023
概括
这项研究引入了一种新方法,用于使用体受体对进行体感应. 这种方法可以准确识别性化合物,即使单个传感器缺乏特异性.
科学领域:
- 化学传感器 化学传感器
- 分析化学 分析化学
- 材料科学 材料科学 材料科学
背景情况:
- 体识别通常需要对单个反体的高传感器特异性.
- 现有的性传感器通常具有有限的灵敏度,并且需要大量的合成努力来开发受体.
- 这些局限性阻碍了性传感器的广泛应用.
研究的目的:
- 开发一种新型的规范化策略,用于使用对的反体受体对进行反体识别.
- 创建一个多功能协议,以制造多种类型的酶体受体对,降低合成复杂度.
- 为了证明这种方法在识别蒸汽阶段的奇拉分析物的有效性.
主要方法:
- 通过将金属氨酸与 (R,R) - 和 (S,S) - 环合金胺基库尔比特[8]uril.uril.结合起来,制造出胺基受体对.
- 使用石英晶体微平衡 (QCM) 作为重力测量传感器来检测分析物.
- 实施一个规范化协议来分析传感器阵列数据以进行反体识别.
主要成果:
- 成功制造了一组由四对反体传感器组成的阵列.
- 尽管单个传感器的选择性较低,但证明了利蒙和1-乙烯胺类分子的精确蒸汽相识别.
- 展示了阿基拉尔金属氨酸的选择会影响对抗选择性特性.
结论:
- 开发的规范化方法使得即使使用非特异单个传感器,也能够有效地进行反对识别.
- 该协议有助于为传感器阵列创建大型的奇拉受体库.
- 这项技术在医疗,农业化学和环境监测领域具有很大的应用潜力.
更多相关视频
相关概念视频
02:05Prochirality
3.8K
The concept of prochirality leads to the nomenclature of the individual faces of a molecule and plays a crucial role in the enantioselective reaction. It is a concept where two or more achiral molecules react to produce chiral products. A typical process is the reaction of an achiral ketone to generate a chiral alcohol. Here, the achiral reactant reacts with an achiral reducing agent, sodium borohydride, to generate an equimolar mixture of the chiral enantiomers of the product. For example, an...
3.8K
02:30Chirality at Nitrogen, Phosphorus, and Sulfur
5.8K
Chirality is most prevalent in carbon-based tetrahedral compounds, but this important facet of molecular symmetry extends to sp3-hybridized nitrogen, phosphorus and sulfur centers, including trivalent molecules with lone pairs. Here, the lone pair behaves as a functional group in addition to the other three substituents to form an analogous tetrahedral center that can be chiral.
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
A consequence of chirality is the need for enantiomeric resolution. While this is theoretically possible for all...
5.8K
02:25Chirality
24.4K
Chirality is a term that describes the lack of mirror symmetry in an object. In other words, chiral objects cannot be superposed on their mirror images. For example, our feet are chiral, as the mirror image of the left foot, the right foot, cannot be superposed on the left foot.
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
Chiral objects exhibit a sense of handedness when they interact with another chiral object. For example, our left foot can only fit in the left shoe and not in the right shoe. Achiral objects — objects that have...
24.4K
00:58¹H NMR Chemical Shift Equivalence: Enantiotopic and Diastereotopic Protons
1.8K
Replacing each alpha-hydrogen in chloroethane by bromine (or a different functional group) yields a pair of enantiomers. Such protons are called prochiral or enantiotopic and are related by a mirror plane. Enantiotopic protons are chemically equivalent in an achiral environment. Because most proton NMR spectra are recorded using achiral solvents, enantiotopic hydrogens yield a single signal.
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
In chiral compounds such as 2-butanol, replacing the methylene hydrogens at C3 produces a pair of...
1.8K