在不常见的年龄组的神经母细胞瘤 - 一个病例系列诊断在细胞学上
Priya Dharmalingam1, Aparna Devi Chenniappan1, Soumya Alashetty1
1Department of Pathology, Kidwai Memorial Institute of Oncology, Bengaluru, India.
Diagnostic cytopathology
|June 16, 2023
概括
成人发病的神经母细胞瘤很少见,但与儿科病例不同,在细胞学上呈现不同,缺乏典型的分子变化. 与儿童神经母细胞瘤相比,这些成年瘤的预后往往较差.
科学领域:
- 在瘤学瘤学.
- 细胞病理学 细胞病理学
- 儿科瘤学 儿科瘤学
背景情况:
- 神经母细胞瘤是一种常见的儿童脑外恶性瘤.
- 在成年人中异常罕见.
研究的目的:
- 调查12岁以上患者通过细胞学诊断的神经母细胞瘤的发病率和特征.
- 描述成年期神经母细胞瘤的临床,细胞形态学和免疫组织化学特征.
主要方法:
- 未来两年 (2020年12月 - 2022年1月) 的前性描述性研究.
- 包括通过精细针吸入细胞学诊断的神经母细胞瘤病例在患者>12年.
- 对临床,细胞形态学和免疫组织化学发现的分析,如果有,则与他的病理学相关性.
主要成果:
- 在青少年和中年成人中发现了三个神经母细胞瘤病例.
- 所有都以腹部质量呈现,在细胞学上具有小圆形细胞形态.
- 病例显示神经内分泌标志物阳性;MYC N放大缺席. 两个是无差异化的,一个差异化很差.
结论:
- 成人发病的神经母细胞瘤表现出与儿科类型不同的特征,缺乏经典组织形态学和分子变化.
- 成年神经母细胞瘤病例的预后似乎比他们的儿科同行更糟糕.
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