具有抗菌选择性的生物相容的化聚类,取决于疏水性碳链的长度
Xiran Shen1,2, Yu Rao2, Di Liu1
1Research School of Polymeric Materials, School of Material Science & Engineering, Jiangsu University, Zhenjiang, 202113, P. R. China. liguo@ujs.edu.cn.
Journal of materials chemistry. B
|June 16, 2023
概括
新的聚胺修饰聚氨薄膜为生物医学植入物提供协同抗菌特性. 这些具有成本效益的表面表现出更好的生物相容性,并有效地对抗包括生物膜在内的阳性和阴性细菌.
科学领域:
- 生物材料科学 生物材料科学
- 聚合物化学 聚合物化学
- 抗微生物材料 抗微生物材料
背景情况:
- 抗生素耐药性需要新的抗菌战略.
- 自然抗微生物 (AMP) 和合成多生物仿真剂 (多) 是有前途的.
- 开发具有高抗菌活性和生物相容性的材料对于生物医学应用至关重要.
研究的目的:
- 合成和表征具有不同侧链长度的阴性多类 (PNBs).
- 开发具有协同作用的抗菌表面的具有成本效益的改性聚氨 (PU) 薄膜.
- 评估这些修饰膜的抗菌选择性,生物相容性和体内疗效.
主要方法:
- 通过环开聚合 (ROP) 合成阴阳性多类 (PNBM,PNBE,PNBB).
- 用合成的多化物 (PU-PNBM,PU-PNBE,PU-PNBB) 修改聚氨 (PU) 薄膜.
- 对阳性 (黄金葡萄球菌) 和阴性 (大肠杆菌) 细菌的抗菌活性,生物膜抑制和小鼠皮肤感染模型中的体内疗效的评估.
主要成果:
- 经过多胺修饰的PU膜显示出有效的协同抗菌活性.
- 通过调整侧链长度来实现抗菌选择性;PNBB (丁侧链) 显示了针对S. aureus和E. coli的广泛活性.
- PU-PNBB膜抑制了细菌生物膜的生长,并在不影响生物相容性的情况下显示出有希望的体内抗菌效率.
结论:
- 方便的合成和表面修饰策略为抗微生物表面应用提供了解决方案.
- 开发的PU-PNBB膜为生物医学植入物提供了更好的生物相容性和强大的抗菌特性.
- 这种方法为在向抗微生物治疗中使用类聚合物提供了一个可行的策略.
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