预测慢性术后疼痛:当前的证据和开发预测生物标志物签名的新计划
Kathleen A Sluka1, Tor D Wager2, Stephani P Sutherland3
1Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, University of Iowa, Iowa City, IA.
Pain
|June 16, 2023
概括
慢性疼痛影响数以百万计的人,但其机制尚不清楚. 急性至慢性疼痛特征 (A2CPS) 计划研究新的疼痛生物标志物,以改善慢性疼痛疾病的诊断和治疗.
科学领域:
- 生物医学研究的研究.
- 治疗疼痛的药物 疼痛的药物
- 翻译科学是翻译的科学.
背景情况:
- 慢性疼痛影响超过5000万美国人,由于对病理生理机制的了解不足,治疗方法不足.
- 目前缺乏用于诊断,跟踪和治疗慢性疼痛的验证的临床生物标志物.
研究的目的:
- 为了解决慢性疼痛生物标志物的需求,美国国立卫生研究院共同基金启动了急性至慢性疼痛标志 (A2CPS) 计划.
- 该A2CPS计划旨在评估候选生物标志物,开发生物签名,并发现用于术后疼痛慢性化治疗的新生物标志物.
主要方法:
- 在A2CPS项目中,研究了广泛的候选生物标志物.
- 这些措施包括基因组,蛋白质组,代谢组,脂质组,神经成像,心理物理,心理和行为评估.
- 这是迄今为止对过渡到慢性术后疼痛的生物标志物进行的最广泛的研究.
主要成果:
- 这篇文章讨论了A2CPS确定用于评估的候选生物标志物.
- 它回顾了包括这些多样化的措施的理由.
- 该研究强调了当前的科学状况,确定了文献上的差距,并概述了A2CPS如何解决这些差距.
结论:
- 该A2CPS计划正在生成关于慢性疼痛生物标志物的宝贵数据和分析资源.
- 这些资源将与科学界分享,以促进进一步的研究和见解.
- 该倡议旨在通过确定可靠的生物标志物来促进慢性疼痛的理解和治疗.
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