COVID-19与ICU获得的殖民和与多药耐药细菌相关的感染之间的关系:一个潜在的多中心前后研究
Louis Kreitmann1,2, Sonia Jermoumi1, Margot Vasseur1
1Médecine Intensive Réanimation, Hôpital R. Salengro, CHU de Lille, Rue E. Laine, 59037, Lille Cedex, France.
严重的COVID-19肺炎患者显示,来自多药耐药细菌的ICU感染增加,但没有殖民. 感染或殖民的整体复合结果在COVID-19和对照组之间没有显著差异.
科学领域:
- 传染性疾病 传染性疾病
- 关键护理医学 关键护理医学
- 微生物学 微生物学
背景情况:
- 患有2019年冠状病毒病 (COVID-19) 严重肺炎的患者通常需要长时间的重症监护室 (ICU) 住院和广泛的抗生素暴露.
- COVID-19对ICU内抗菌素耐药性的发展的影响在很大程度上是未知的.
- 了解这种关系对于管理医院感染和优化抗生素管理至关重要.
研究的目的:
- 调查COVID-19与多药耐药 (MDR) 细菌在ICU中的殖民和/或感染发生率之间的关联.
- 为了比较COVID-19患者和对照队列之间的ICU获得的MDR细菌累积发病率结果.
主要方法:
- 在法国的7个ICU进行了前后观察性前后研究.
- 连续感染SARS-CoV-2确诊的患者和ICU停留时间>48小时被前性跟踪了28天.
- 在入院后和每周一次,对MDR细菌殖民的系统查进行;患者与历史对照组进行了比较.
主要成果:
- 总共有367名COVID-19患者与680名对照人群进行了比较.
- 在调整了混杂因素后,由于MDR细菌 (ICU-MDR-inf) 引起的ICU获得感染的发生率在COVID-19患者中显著更高 (aHR 2.50,95%CI 1.90-3.28).
- 然而,MDR细菌殖民 (ICU-MDR-col) 的发生率没有显著差异,ICU-MDR-col和/或ICU-MDR-inf的复合结果在组之间没有显著差异 (aHR 1.39,95% CI 0.91-2.09).
结论:
- COVID-19患者经历了由多药耐药细菌引起的ICU获得感染的更高发病率.
- 在将COVID-19患者与对照进行比较时,该研究没有发现殖民和/或感染的复合结果存在显著差异.
- 这些发现凸显了针对COVID-19患者特定MDR细菌感染的有针对性的监测和感染控制措施的必要性.
更多相关视频
07:16Development of a Polymicrobial Colony Biofilm Model to Test Antimicrobials in Cystic Fibrosis
Published on: September 20, 2024
09:49Investigation of Microbial Cooperation via Imaging Mass Spectrometry Analysis of Bacterial Colonies Grown on Agar and in Tissue During Infection
Published on: November 18, 2022
相关概念视频
Development of Antibiotic Resistance
Factors Affecting the Risk of Infection
The integrity and count of the white blood cells help the body resist pathogens and fight infection. When impaired, it reduces the body's resistance to pathogens. The acidic pH levels of the gastrointestinal, genitourinary tracts, and skin...
Healthcare Associated Infections I: Iatrogenic, Exogenic and Endogenic
HAIs significantly increase the cost of health care. Extended stays in healthcare institutions, increased disability, increased costs of medications, including specialized antibiotics, and prolonged recovery times add to the patient's expenses and the healthcare institution and funding bodies.
Infection
The chain begins with pathogens: bacteria, viruses, fungi, prions, or parasites such as protozoa helminths. These can be present on the skin as transient or resident flora, or they can be acquired from the environment. Identifying and treating the type of infection and...
Defense Against Bacterial Pathogens
Phagocytes
Phagocytes are the frontline soldiers of the immune system. They include neutrophils and macrophages. Neutrophils are the most abundant type of white blood cell and are quickly mobilized to the site of infection. Macrophages are larger cells that patrol...
Urinary Tract Infection II: Pathophysiology
