影响前列腺癌焦点治疗合格候选人选择的因素

相关实验视频

Updated: Jul 26, 2025

11:07

Focal Laser Ablation of Prostate Cancer: An Office Procedure

Published on: March 30, 2021

7.9K

Toshikazu Takeda¹, Keiichi Narita², Yota Yasumizu³

¹Department of Urology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-Ku, Tokyo, 160-8582, Japan. ttakeda8156@keio.jp.

World journal of urology

|June 16, 2023

概括

选择适合前列腺癌 Hemi-ablative焦点治疗 (FT) 的候选人至关重要. 活检阴性叶的低PI-RADS得分预测了资格,可能改善FT结果并减少错过的癌症.

科学领域:

泌尿器科泌尿器科泌尿器科泌尿器科
在瘤学瘤学.
医疗成像医学成像

背景情况:

焦点治疗 (FT) 提供了一种治疗前列腺癌的选择,旨在最大限度地减少副作用.
准确的患者选择是为 hemi-ablative FT 的重大挑战.
确定符合资格的预测因素对于成功实施FT至关重要.

研究的目的:

调查预测前列腺癌患者接受 Hemi-ablative焦点治疗资格的因素.
分析MRI和活检特征在FT患者选择中的作用.

主要方法:

对54名单边前列腺癌患者进行了彻底前列腺切除术的回顾性分析.
根据特定的活检和MRI标准 (前列腺成像报告和数据系统版本2) 选择了患者.
根据活检阴性叶和病理阶段的瘤特征,评估了对 Hemi-ablative FT 的资格.

主要成果:

在54名患者中,有29名患者 (53.7%) 被认为有资格接受 Hemi-ablative FT.
活检阴性叶中的PI-RADS得分<3被确定为FT资格的独立预测因子 (p=0.016).
不符合条件的患者在活检阴性叶中往往具有更高的格里森得分 (GS ≥ 3+4),有时与PI-RADS得分<3相关.

结论:

活检阴性叶的PI-RADS评分是选择FT候选人的关键因素.
利用PI-RADS得分可以帮助防止在FT候选人选择中忽略显著的前列腺癌.
通过MRI评估改善患者选择可以提高前列腺癌的FT结果.

关键词:

活检是为了检查生物质.焦点治疗是一种焦点疗法.磁共振成像技术磁共振成像技术病理学病理学病理学前列腺癌是什么意思前列腺癌是什么意思

相关概念视频

02:57

Targeted Cancer Therapies

7.7K

The targeted cancer therapies, also known as “molecular targeted therapies,” take advantage of the molecular and genetic differences between the cancer cells and the normal cells. It needs a thorough understanding of the cancer cells to develop drugs that can target specific molecular aspects that drive the growth, progression, and spread of cancer cells without affecting the growth and survival of other normal cells in the body.
There are several types of targeted therapies against...

7.7K

01:29

Factors Affecting Protein-Drug Binding: Patient-Related Factors

Protein-drug binding, a pivotal aspect of pharmacokinetics, is subject to considerable variability influenced by an array of patient-related factors. The intricate interplay of age, individual differences, and pathological conditions significantly impact the binding dynamics and subsequent pharmacological effects.
Age stands as a key determinant in protein-drug binding. Neonates, characterized by low albumin content, experience heightened concentrations of unbound drugs such as phenytoin and...

01:21

Factors Affecting Drug Response: Overview

2.0K

When it comes to infants and young children, they are typically administered smaller doses of medication in comparison to adults. This is primarily because their organ functions still need to fully develop, meaning their bodies are not as efficient at metabolizing or eliminating drugs. Additionally, their blood-brain barrier is more permeable than in adults. As a result, high concentrations of drugs can easily penetrate the central nervous system (CNS), potentially leading to neurological...

2.0K

02:50

Combination Therapies and Personalized Medicine

5.0K

Combining two or more treatment methods increases the life span of cancer patients while reducing damage to vital organs or tissue from the overuse of a single treatment. Combination therapy also targets different cancer-inducing pathways, thus reducing the chances of developing resistance to treatment.
The combination of the drug acetazolamide and sulforaphane is a good example of combination therapy to treat cancer. The cells in the interior of a large tumor often die due to the hypoxic and...

5.0K

01:25

Elements Crucial for Effective Psychotherapy

Research has highlighted several critical factors that influence the effectiveness of psychotherapy, such as the therapeutic alliance, the therapist, and the client.
The Therapeutic Alliance
The therapeutic alliance refers to the relationship between the therapist and the client. The alliance strengthens when the therapist and the client engage in a nurturing, supportive, trusting, empathetic, and respectful relationship, improving therapeutic outcomes. Therapists must monitor this relationship...