来自中国东部的学龄前儿童的尿路抗生素度和健康风险评估
Juan Wen1, Shijie Geng1, Lijun Zhu1
1Nanjing Maternity and Child Health Care Institute, Women's Hospital of Nanjing Medical University, Nanjing Maternity and Child Health Care Hospital, Nanjing, 210004, Jiangsu, China.
概括
在中国东部的幼儿中发现了广泛的抗生素暴露,在尿液中检测到41种抗生素. 饮食,特别是海鲜和肉类消费,与抗生素暴露增加和潜在的健康风险相关.
科学领域:
- 环境科学 环境科学
- 毒理学 毒理学 毒理学
- 儿科健康 儿科健康
背景情况:
- 关于幼儿抗生素体内负担的数据有限.
- 了解学龄前儿童的抗生素暴露和健康风险至关重要.
研究的目的:
- 评估中国东部学龄前儿童的抗生素暴露水平.
- 评估与抗生素暴露相关的潜在健康风险.
- 为了检查饮食模式和抗生素暴露之间的关系.
主要方法:
- 从508名学龄前儿童的尿样中分析了50种抗生素的UPLC-MS/MS分析.
- 用于风险评估的危险系数 (HQ) 和危险指数 (HI) 的计算.
- 多变量逻辑回归用于分析饮食与抗生素暴露相关性.
主要成果:
- 在100%的儿童尿液中检测到抗生素,其中硫胺,类,β-乳酸盐,类和醇是最常见的.
- 10.0%的儿童的微生物危险指数超过1,主要是由于西普洛克萨.
- 较高的海鲜消费与多种类型的抗生素暴露的增加有关;肉/蛋消费与人类抗生素有关.
结论:
- 中国东部的学龄前儿童广泛暴露于抗生素.
- 包括海鲜和肉类摄入在内的饮食模式与更高的抗生素暴露有关.
- 需要进一步的研究才能充分了解这种暴露对健康的影响.
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