毛细血管稀缺:脏和心血管疾病中的缺失环节?
Floor M E G Steegh1, Anke A Keijbeck1, Patrick A de Hoogt2
1Department of Pathology, Maastricht University Medical Centre+, Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands.
Angiogenesis
|June 16, 2023
概括
毛细血管稀疏或血管密度降低与慢性病 (CKD) 和心血管问题有关. 这篇综述强调了它在脏和系统中的存在,强调了对其原因和影响进行进一步研究的需要.
科学领域:
- 腎臟病學 (nephrology) 是一種醫學專業.
- 心脏病学 心脏病学
- 血管生物学 血管生物学
背景情况:
- 患有慢性病 (CKD) 的患者面临心血管疾病发病率和死亡率的风险增加.
- 毛细血管稀疏,降低血管密度,被认为是CKD和心血管疾病的原因和后果.
- 内皮功能障碍和毛细血管损失是脏和全身血管系统的关键病理特征.
研究的目的:
- 在慢性脏病和心血管疾病的背景下,审查关于毛细血管稀疏性的人类活检研究的文献.
- 探索脏和全身毛细血管稀缺之间的关系.
- 强调毛细血管完整性在治疗脏和心血管疾病方面的重要性.
主要方法:
- 发表的人体活检研究的系统审查.
- 对毛细血管密度的非侵入性测量结果的分析.
- 综合证据,将毛细血管稀缺与CKD和心血管风险因素联系起来.
主要成果:
- 毛细血管稀缺发生独立于功能下降的原因.
- 淋巴细胞缩可能表明早期内皮功能障碍;周周毛细管损失与晚期病有关.
- 系统毛细管稀疏性可检测到在白蛋白尿 (早期CKD) 和心血管风险因素,影响各种组织的个体.
结论:
- 毛细血管稀缺是CKD和心血管疾病中的重要发现,影响脏和全身血管.
- 脏和全身毛细血管稀缺之间的因果关系和时间序列尚不清楚,需要进一步调查.
- 保持毛细血管完整性对于预防和管理脏和心血管疾病至关重要.
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