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通过DNA甲基化调节的PSRC1是LGG免疫疗法的新目标

Zhendong Liu¹, Wenjia Liang², Qingyun Zhu³

¹Department of Surgery of Spine and Spinal Cord, Henan Provincial People's Hospital, People's Hospital of Zhengzhou University, People's Hospital of Henan University, No.7 Weiwu Road, Jinshui District, Zhengzhou, 450003, Henan Province, China.

Journal of molecular neuroscience : MN

|June 16, 2023

概括

富含氨酸和氨酸的卷状卷轴1 (PSRC1) 在低级质瘤 (LGG) 中高度表达,与恶性瘤和低生存率相关. PSRC1可以作为LGG的潜在生物标志物和免疫治疗标.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学遗传学是一个

背景情况:

富含氨酸和氨酸的螺旋线圈1 (PSRC1) 被认为是各种癌症的一个瘤基因.
它在低级质瘤 (LGG) 中的作用仍然在很大程度上未被探索.
了解PSRC1在LGG中的功能对于开发新的治疗策略至关重要.

研究的目的:

研究PSRC1在较低级别质瘤 (LGG) 中的作用和临床意义.
探索PSRC1表达,临床特征和LGG患者预后之间的关系.
为了确定潜在的分子机制和治疗点,涉及PSRC1在LGG.

主要方法:

在22个机构和1126个LGG数据库样本中分析PSRC1表达.
与临床特征的相关性分析 (WHO等级,复发,IDH状态).
预后分析,DNA甲基化分析,免疫细胞透分析,共同表达和KEGG通路分析.

主要成果:

在更恶性的LGG亚型 (更高的WHO等级,复发,IDH野生类型) 中,PSRC1的表达显著更高.
高PSRC1表达独立预测LGG患者的总生存时间较短.
PSRC1表达与DNA甲基化,免疫细胞透和免疫检查点表达相关.
凯格分析确定了MAPK信号传递和焦点粘附途径可能参与其中.

结论:

在低度质瘤的进展中,PSRC1起着致病作用.
PSRC1表达作为LGG的预后生物标志物.
在LGG中,PSRC1代表了免疫治疗的潜在标.

关键词:

生物标志物生物标志物通过DNA甲基化.较低级别的质瘤在PSRC1中,它是PSRC1.致病性基因的病原性基因

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