儿科非典型外神经细胞瘤:临床特征和生存结果
Liang Zhang1,2, Sheng Fang3, Angsi Liu2
1National Cancer Center/National Clinical Research Center for Cancer/Hebei Cancer Hospital, Chinese Academy of Medical Sciences, Langfang, China.
概括
儿科非典型外神经细胞瘤 (EVN) 显示,尽管有积极的治疗,预后仍然不佳. 高基-67指数预测瘤的进展,需要手术切除,然后进行放射和化疗.
科学领域:
- 儿科神经瘤学 儿童神经瘤学
- 瘤病理学和遗传学
- 临床结果研究研究的临床结果.
背景情况:
- 室外神经细胞瘤 (EVN) 是一种非常罕见的儿科脑瘤.
- 关于儿科非典型EVN的治疗和预后的数据有限.
- 这项研究旨在确定儿科非典型EVN的临床放射学特征和结果.
研究的目的:
- 调查儿童非典型外神经细胞瘤 (EVN) 的临床和放射性特征.
- 评估非典型EVN的儿科患者的治疗结果和预后因素.
主要方法:
- 在2011年1月至2019年12月期间被诊断患有非典型EVN的儿科患者的回顾性评估.
- 对人口统计数据,手术干预,辅助疗法和患者结果的分析.
- 病理发现的相关性,包括Ki-67指数,与疾病进展.
主要成果:
- 确定了7名患有非典型EVN的儿科患者,男性占主导地位.
- 额叶和叶是最常见的部位;总切除率达到85.7%.
- 所有瘤都表现出高Ki-67指数,71.4%接受了辅助疗法,但71.4%经历了进展,中位数为48个月的无进展生存期.
结论:
- 儿科非典型的EVN即使在积极的多式疗法治疗后,预后也很差.
- 瘤进展与高Ki-67指数显著相关.
- 手术切除是首要的,术后建议使用辅助放射治疗和化疗.
更多相关视频
相关概念视频
Aneurysm II: Clinical Manifestations and Diagnostic Studies
11
Thoracic, aortic arch and abdominal aneurysms are significant vascular conditions that can present with various clinical manifestations and lead to serious complications. Understanding these manifestations and the appropriate diagnostic studies is essential for effective management and treatment.Thoracic Aortic AneurysmsThoracic aortic aneurysms often remain asymptomatic until they reach a size that impinges on adjacent structures. They typically cause deep, diffuse chest pain that radiates to...
11
Treatment Resistant Cancers
3.4K
Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...
3.4K


