在一般人群中预测与CT衍生的肺总体积:ImaLife研究
Hendrik J Wisselink1, Danielle J D Steerenberg1, Mieneke Rook1,2
1Department of Radiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
PloS one
|June 16, 2023
概括
从全球肺功能倡议 (GLI) 模型中预测的总肺容量 (TLC) 显著高估了健康成年人的实际肺总体积 (TLV). 这表明,对于准确的临床评估,可能需要直接测量肺体积.
科学领域:
- 肺部医学 肺部医学
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 全球肺功能倡议 (GLI) 模型预测是评估肺部疾病肺部体积的标准.
- 与计算机断层扫描 (CT) 衍生的肺总体积 (TLV) 相比,GLI预测的肺体积的准确性尚未得到充分证实.
研究的目的:
- 为了比较2021年全球肺功能倡议 (GLI-2021) 模型预测的肺总容量 (TLC) 与CT衍生的肺总体积 (TLV) 在健康成年人队列中.
主要方法:
- 来自Imaging in Lifelines (ImaLife) 队列的151名女性和139名男性 (45-65岁) 接受了低剂量启发性胸部CT.
- 肺总体积 (TLV) 用自动化CT分析进行测量.
- 布兰德-阿尔特曼分析将CT衍生的TLV与GLI-2021预测的TLC进行了比较,并在从未吸烟者中重复分析.
主要成果:
- CT衍生的TLV在女性中平均为4.7±0.9 L,在男性中平均为6.2±1.2 L.
- GLI-2021预测TLC高估了TLV,显示系统偏差为1.0L (女性) 和1.6L (男性).
- 观察到很高的变化,一致性范围从3.2L (女性) 到4.2L (男性) 之间,在从未吸烟者中一致.
结论:
- 来自GLI-2021模型的预测TLC在健康成年人中大大高估了CT衍生的TLV,其精度和准确性较低.
- 对于需要准确或精确的肺体积量化的临床场景,建议直接测量肺体积,而不是GLI预测.
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