关于男性不孕症的eNOS多态:更新的系统性审查和元分析
Zhihai Teng1, Hu Wang, Fengran Guo
1Department of Urology, The Second Hospital of Hebei Medical University, Shijiazhuang, China.
Medicine
|June 16, 2023
概括
内皮氧化合成酶 (eNOS) 基因多态化rs2070744和rs1799983与男性不孕症风险增加有关. 在亚洲人群中,eNOS rs61722009多态也可能构成男性不孕症的风险.
科学领域:
- 遗传学和生殖医学 遗传学和生殖医学
- 分子生物学和生物化学 分子生物学和生物化学
背景情况:
- 男性不孕症是全球重要的健康问题.
- 内皮氧化合成酶 (eNOS) 在生殖功能中起着至关重要的作用.
- 目前正在研究eNOS基因的遗传变异,作为男性不孕症的潜在贡献者.
研究的目的:
- 进行一项元分析,研究三个特定的eNOS基因多态 (rs2070744,rs1799983和rs61722009) 与男性不孕症风险之间的关联.
- 综合来自多项研究的现有证据,以便更好地了解这些遗传关联.
主要方法:
- 在PubMed,Medline和Web of Science中对2022年7月1日之前发表的研究进行了全面的文献搜索.
- 搜索策略的目标是针对 eNOS 基因及其与男性不孕症相关的多形态.
- 使用MetaGenyo,Stata 12,试验序列分析和GTEx进行了统计分析.
主要成果:
- 该元分析包括13项研究,其中包括6518例病例和5461例对照,针对三个eNOS多态.
- eNOS rs2070744的多态性与各种遗传模型中男性不孕症风险增加有显著的关联.
- eNOS rs1799983的多态性也显示出与男性不孕症风险增加的显著相关性.
- 分层分析表明,eNOS rs61722009多态可能是男性不孕症的风险因素,特别是在亚洲人中.
结论:
- eNOS rs2070744和rs1799983的多态是男性不孕症的确诊危险因素.
- 在亚洲人群中,eNOS rs61722009多态呈现男性不孕症的潜在风险.
- 这些发现强调了特定的eNOS基因变异在男性不孕症病因学的重要性.
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