叶酸补充剂对慢性缩性胃炎的作用基于MTHFR C677T多态性
Siya Kong1,2, Guoxin Zhang1,2, Zhen Yang1,2
1Department of Gastroenterology, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Medicine
|June 16, 2023
概括
叶酸 (FA) 补充改善了慢性缩性胃炎 (CAG) 病变,特别是在患有MTHFR 677TT基因型的患者中. 这凸显了FA在管理CAG及其遗传预测因子方面的作用.
科学领域:
- 胃肠病学 胃肠病学
- 遗传学 是一个遗传学.
- 营养科学 营养科学
背景情况:
- 慢性缩性胃炎 (CAG) 组织病理学与甲基基酸减少酶 (MTHFR) 677TT基因型有关.
- 在脂肪酸 (FA) 代谢中,MTHFR起着关键作用.
- 在MTHFR C677T基因型可以预测CAG的进展.
研究的目的:
- 评估FA补充剂在没有H.pylori感染的CAG患者的疗效.
- 为了研究MTHFR C677T基因型作为CAG的预测因素.
- 评估FA和维生素B12对胃组织病理学的影响.
主要方法:
- 96名CAG患者 (21-72岁) 接受了单独的weifuchun (WFC),WFC + FA或WFC + FA + 维生素B126个月.
- 使用胃炎/肠道转化成形 (OLGIM) 阶段的操作链接来评估组织病理结果.
- 对MTHFR C677T (rs 1801133) 进行了基因型鉴定.
主要成果:
- 与WFC一起服用FA补充剂显著改善了与WFC单独相比的缩性病变 (78.1%对比53.3%,P=.04).
- 与CC/CT基因型相比,MTHFR 677TT基因型的患者在缩性/肠道代塑性病变中表现出更好的改善 (P=.02).
结论:
- 6个月每天服用5mg的FA补充剂可提高CAG患者的胃缩状态,特别是OLGIM I/II阶段.
- 在CAG管理中,MTHFR 677TT基因型表明需要快速有效的FA治疗.
- 这项研究是首次证明MTHFR 677TT基因型对CAG.FA治疗反应的影响.
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