尿中对功能生物标志物的值效应:来自重复测量研究的证据
Jingtao Wu1, Jing Xu2, Meiduo Zhao1
1Department of Epidemiology and Biostatistics, Institute of Basic Medical Sciences Chinese Academy of Medical Sciences, School of Basic Medicine Peking Union Medical College, Beijing 100005, China; Center of Environmental and Health Sciences, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100005, China.
Ecotoxicology and environmental safety
|June 16, 2023
概括
暴露与慢性病 (CKD) 和高蛋白尿症有关,并确定了特定的值. 对的损伤随着年龄的增长而恶化,这凸显了对暴露控制的需要,特别是在老年人中.
科学领域:
- 环境健康 环境健康
- 腎臟病學 (nephrology) 是一種醫學.
- 毒理学 毒理学 毒理学
背景情况:
- 慢性病 (CKD) 是一个全球性的健康问题.
- 暴露是损伤的潜在危险因素,但对其影响和值的研究有限.
研究的目的:
- 调查暴露与功能生物标志物之间的关联.
- 为了确定暴露对功能潜在的值影响.
- 为了检查的毒性如何随着年龄的增长而改变.
主要方法:
- 一项重复测量研究分析了中国金州183名成年人的641个观察结果 (2017-2021).
- 评估功能时使用尿中的白蛋白与肌素的比率 (UACR) 和估计的淋巴膜过率 (eGFR).
- 统计模型,包括通用混合模型和两部分线性线条混合模型,用于分析剂量反应关系和值效应.
主要成果:
- 尿路与慢性病的风险增加 (OR=1.29) 和更高的UACR (10.16%的增加) 相关.
- 尿中和eGFR之间没有发现显著的关联.
- 观察到值效应,UACR的拐点为2.74μg/L,eGFR的拐点为3.95μg/L.
- 暴露对老年人损伤的影响更大.
结论:
- 暴露与不良的功能标志物有关,包括CKD和白色素尿,确定了值.
- 的毒性作用在老年人中更为明显.
- 对暴露水平的监督对于预防损伤至关重要,特别是在脆弱的老年人群中.
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