乳腺MRI可以预测乳腺癌新辅助化疗后的病理反应吗? 一个回顾性队列研究
Lily Kwak1, Cesar Santa-Maria2, Philip Di Carlo1
1Russell H. Morgan Department of Radiology and Radiological Science, Johns Hopkins Medicine, 601 North Caroline St, Baltimore, MD 21287, United States of America.
Clinical imaging
|June 16, 2023
概括
乳腺MRI在新辅助化疗 (NAC) 后的侵袭性乳腺癌中适度预测治疗反应,准确度约为69%. 预测值因癌症受体状态而异,突出显示需要量身定制的评估.
科学领域:
- 在瘤学瘤学.
- 放射学 放射学是一门学科.
- 医疗成像医学成像
背景情况:
- 新辅助化疗 (NAC) 是乳腺癌的标准,需要成像来评估手术前的治疗反应.
- 乳腺磁共振成像 (MRI) 用于评估NAC后的治疗疗效.
研究的目的:
- 为了评估乳腺磁共振成像 (MRI) 的结果指标在侵袭性乳腺癌患者治疗NAC.
- 评估MRI在确定对NAC病理反应的预测准确度.
主要方法:
- 对225名患有侵袭性乳腺癌的患者进行了回顾性分析,这些患者接受了NAC前后的乳腺MRI.
- 核磁共振成像研究被分类为放射性完全响应 (rCR) 或非rCR.
- 手术病理报告确定了病理完整反应 (pCR) 或非pCR;计算了MRI准确度指标.
主要成果:
- 在预测PCR方面,MRI的整体准确性为69%,灵敏度为76%和特异性为56%.
- 积极预测值 (PPV) 为77%,负预测值 (NPV) 为55%.
- PPV与乳腺癌受体状态显著相关 (p=0.004).
结论:
- 乳腺MRI在预测NAC对侵袭性乳腺癌的病理反应方面表现出中度准确性 (69%).
- 磁力共振成像的积极预测值受到患者特定癌症受体状态的显著影响.
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