法莫蒂丁对COVID-19后感染引起的认知和行为功能障碍的影响:一项随机,双盲和安慰剂控制的随机研究
Sara Momtazmanesh1, Sahar Ansari2, Zahra Izadi1
1Psychiatric Research Center, Roozbeh Hospital, Tehran University of Medical Sciences, Tehran, Iran.
Journal of psychosomatic research
|June 16, 2023
概括
在COVID-19后的患者中,法莫蒂丁有效地改善了认知障碍,抑郁和焦虑症状. 这种组胺H2受体对手在为期12周的随机对照试验中证明了安全性和有效性.
科学领域:
- 神经学 神经学
- 药理学 药理学是指药理学的学科.
- 传染性疾病 传染性疾病
背景情况:
- 后COVID-19条件经常包括认知障碍,抑郁和焦虑.
- 基因组H2受体对抗剂,如famotidine,正在研究神经和心理症状的潜在治疗益处.
研究的目的:
- 评估famotidine在改善COVID-19感染后患者的认知障碍,抑郁和焦虑症状方面的疗效和安全性.
- 评估famotidine对后COVID-19人口认知功能和情绪障碍的影响.
主要方法:
- 一个为期12周的随机对照试验,涉及50名被诊断患有COVID-19的患者.
- 患者被随机分配给接受 famotidine (40 mg 每天两次) 或安慰剂.
- 认知功能使用迷你心理状态检查 (MMSE) 和蒙特利尔认知评估 (MoCA) 尺度进行评估,而抑郁和焦虑则使用汉密尔顿抑郁评分表 (HAM-D) 和汉密尔顿焦虑评分表 (HAM-A) 进行评估.
主要成果:
- 与安慰剂相比,Famotidine治疗在第6周和第12周的MMSE和MoCA得分显著改善 (p <0.014).
- 接受法莫蒂丁治疗的患者在第6周和第12周的HAM-D和HAM-A得分显著降低 (p <0.04).
- 在 famotidine 和安慰剂组之间没有观察到不良事件频率的显著差异.
结论:
- 法莫蒂丁是一种安全有效的治疗认知障碍,抑郁症和与COVID-19后条件相关的焦虑症状.
- 这些发现支持使用famotidine作为治疗选择来管理COVID-19的神经精神病学后果.
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