克雷索尔异构体对大夫尼亚大片的繁殖和基因表达的影响
Fulgence Jacob Macha1, Hyungjoon Im2, Kyungtae Kim3
1Department of Civil and Environmental Engineering, Pusan National University, Busan 46241, Republic of Korea.
The Science of the total environment
|June 16, 2023
概括
克雷索尔有害于水生动物的繁殖,减少了后代,并延迟了大夫尼亚大的发育. 然而,这些化合物在生物体中没有显著的生物积累.
科学领域:
- 环境毒理学环境毒理学
- 生态毒理学 生态毒理学
- 水生毒理学 水生毒理学
背景情况:
- 克雷索尔是由于消毒剂的使用而造成的常见淡水污染物.
- 关于水生物种慢性生殖和基因表达毒性的数据有限.
研究的目的:
- 调查克雷索尔异构体对大夫尼的繁殖和基因表达的慢性毒性.
- 评估水生生物体中克雷索尔异构体的生物度行为.
主要方法:
- 在21天内对大夫尼亚大进行慢性毒性测试.
- 生殖输出和身体尺寸测量.
- 基因表达分析和生物度研究.
主要成果:
- p-cresol的毒性比o-和m-cresol的毒性更高. p-cresol的毒性比o-和m-cresol更高.
- 克雷索尔降低了后代数量,并延迟了繁殖.
- 新生儿的身体长度受到m-和p-cresol在次致命水平的影响,但体重没有受到影响.
- 没有观察到基因转录的显著变化.
- 大夫尼马格纳很快消除了克雷索尔,这表明其生物积累潜力很低.
结论:
- 克雷索尔对水生无脊椎动物构成繁殖风险.
- 虽然克雷索尔没有生物积累性,但可以影响水生无脊椎动物的发育和繁殖.
- 需要进一步的研究来了解长期的基因表达效应.
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