重新考虑在母体血清查中使用种族调整
Christina C Pierre1, Dina N Greene2, Shani Delaney3
1Department of Pathology and Laboratory Medicine, Penn Medicine Lancaster General Health, Lancaster, PA; Department of Pathology and Laboratory Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.
American journal of obstetrics and gynecology
|June 16, 2023
概括
使用种族进行母体血清查是有问题的,因为种族是一种社会构造. 研究显示了相互矛盾的结果,导致建议放弃基于种族的切断对胎儿异常风险评估.
科学领域:
- 生物化学 生物化学
- 遗传学 是一个遗传学.
- 社会学 社会学 社会学
背景情况:
- 孕产妇血清查 (MSS) 使用生物标志物评估胎儿异常风险.
- 目前,实验室在MSS生物标志物中使用种族特定的截止值.
- 作为医学中的生物分类器,种族的科学基础受到质疑.
研究的目的:
- 评估在母体血清查中使用种族的有用性和有效性.
- 探索MSS生物标志物的种族差异研究中结果矛盾的原因.
- 在产前查中提出基于种族的风险评估的替代方案.
主要方法:
- 关于MSS生物标志物度的种族差异的大型队列研究的综述.
- 在现有文献中分析潜在的遗传和社会经济混因素.
- 为相互矛盾的研究结果提供解释.
主要成果:
- 关于MSS生物标志物度的种族差异存在相互矛盾的结果.
- 种族是一种社会构造,而不是一个独特的生物分类.
- 遗传和社会经济因素可能导致种族群体之间观察到的生物标志物变异.
结论:
- 应停止在母体血清查中使用种族.
- 需要进一步的研究来确定影响生物标志物水平的社会经济和环境因素.
- 开发种族无关的风险估计对于公平的产前查至关重要.
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