在中部前额叶皮层中选择性PI3-激酶控制行动策略的子单位
Rachel A Davies1, Britton R Barbee2, Yesenia Garcia-Sifuentes3
1Department of Pediatrics, Emory University School of Medicine, Emory National Primate Research Center, Emory University, Children's Healthcare of Atlanta, USA.
Neurobiology of learning and memory
|June 16, 2023
概括
在大脑中抑制PI3-酶 (PI3K) p110β会影响寻找目标的行为. 过多或过少的PI3K p110β都会破坏决策,有利于基于习惯的行为.
科学领域:
- 神经科学是一个神经科学.
- 分子生物学分子生物学
- 行为科学 行为科学
背景情况:
- 酸3-酶 (PI3K) 信号由可卡因激活,并影响其行为效应.
- 介面前额皮层PI3K的p110β亚单元与可卡因诱导的行为变化有关.
研究的目的:
- 为了调查PI3K p110β对决策的控制是否是神经元.
- 确定PI3K p110β在未使用过毒品的小鼠中对奖励相关决策的作用.
主要方法:
- 在小鼠中介前额叶皮层中,PI3K p110β亚单元的遗传沉默.
- 在暴露于可卡因后的小鼠和在未使用过毒品,经过食物训练的小鼠中进行行为测试.
主要成果:
- 在暴露于可卡因后,p110β的神经沉默增强了行动灵活性.
- 在未服用过药物的小鼠中,降低PI3K p110β导致从目标寻求转向基于习惯的行为,涉及到核 accumbens.
结论:
- PI3K p110β对目标导向行为的调节遵循一个反转的U形函数.
- PI3K p110β的失调,无论是过量还是缺乏,都会损害目标寻求,并促进习惯性行为.
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