治疗癌症的Kushen注射化合物的辅助作用:系统性审查的概述
Chenchen Li1, Dong Niu1, Ranpei Zhu1
1Graduate School, Henan University of Chinese Medicine, Zhengzhou, 450046, China.
复合库申注射 (CKI) 显示出作为辅助癌症治疗的潜力,特别是在非小细胞肺和消化系统瘤中. 然而,目前的证据质量较低,需要进一步的高质量研究来证实其有效性.
科学领域:
- 在瘤学瘤学.
- 药理学 药理学是指药理学的学科.
- 基于证据的医学基于证据的医学.
背景情况:
- 复合库申注射 (CKI) 是一种传统的中国草药,来源于Sophora flavescens Aiton和Heterosmilax japonica Kunth.
- 它含有类化合物,如 (MAT) 和氧 (OMT),以其抗瘤特性而闻名.
- 在中国,CKI经常被用作各种癌症的辅助疗法.
研究的目的:
- 重新评估CKI辅助癌症治疗的现有系统审查和元分析 (SRs/MAs).
- 为CKI的临床应用提供全面的参考.
主要方法:
- 搜索了四个主要的英语数据库 (PubMed,Embase,Web of Science,Cochrane Library) 的SRs/MAs,直到2022年10月.
- 包括18个SR/MA,涵盖各种癌症,如非小细胞肺癌,肝癌,胃癌和乳腺癌.
- 使用AMSTAR 2评估方法质量,使用PRISMA报告完整性,使用GRADE评估证据质量.
主要成果:
- 包含的SRs/MAs的方法质量通常非常低.
- 在所有研究中,报告的完整性大多是充足的.
- GRADE评估表明,与非小细胞肺癌和消化系统瘤相关的9个指标的证据质量中等;其他结果的证据质量低至非常低.
结论:
- CKI显示出作为瘤疾病的辅助治疗的潜力,特别是非小细胞肺癌和消化系统瘤.
- 目前的证据库,主要来自SRs/MAs,方法和证据质量不佳.
- 需要更多高质量,基于证据的医学研究来最终证实CKI在癌症辅助治疗中的有效性.
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