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针对米R-204-5p的AP1S2对于乳头甲状腺癌是必要的

Yulu Gu¹, Xin Zhang², Yong Li³

¹Department of Epidemiology and Biostatistics, School of Public Health, Jilin University, Changchun, 130021, PR China; National Health Commission Key Laboratory of Radiobiology, School of Public Health, Jilin University, Changchun, 130021, PR China.

Molecular and cellular endocrinology

|June 16, 2023

概括

微RNA-204-5p (miR-204-5p) 在乳头甲状腺癌 (PTC) 中充当瘤抑制剂. 在PTC组织和血清中较低的miR-204-5p水平与增加的PTC风险和疾病进展相关.

科学领域:

在瘤学瘤学.
分子生物学分子生物学
遗传学是一个遗传学.

背景情况:

微RNA-204-5p (miR-204-5p) 被认为是各种癌症中的瘤抑制剂.
它在乳头甲状腺癌 (PTC) 病原发生中的特定作用仍然未被探索.

研究的目的:

为了调查miR-204-5p在皮肤状甲状腺癌中的参与.
为了确定miR-204-5p在PTC患者的诊断和预后意义.

主要方法:

定量实时PCR测量miR-204-5p在PTC组织和血清中的表达.
细胞生物学实验评估miR-204-5p对PTC细胞行为的功能影响.
RNA测序 (RNA-seq),iTRAQ和生物信息学预测以识别miR-204-5p目标.

主要成果:

与正常组织相比,miR-204-5p在PTC组织中显著下调.
血清miR-204-5p水平在PTC患者中较低,与PTC风险相关.
在患有PTC和良性病变的患者中,表达明显较低.
miR-204-5p抑制了PTC细胞的增殖,迁移,入侵和细胞周期的进展,同时诱导了细胞亡.
AP1S2被确定为miR-204-5p的直接目标.

结论:

miR-204-5p在乳头甲状腺癌中起到瘤抑制作用.
在抑制PTC进展方面,miR-204-5p/AP1S2轴起着至关重要的作用.
血清miR-204-5p可以作为PTC风险评估的潜在生物标志物.

关键词:

AP1S2 AP1S2 AP1S2 AP1S2 AP1S2 AP1S2 乳头甲状腺癌是一种乳头甲状腺癌.血清生物标志物的血清生物标志物在 miR-204-5p 中.

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