超声波局部化显微镜学
Stefanie Dencks1, Georg Schmitz1
1Lehrstuhl für Medizintechnik, Fakultät für Elektrotechnik und Informationstechnik, Ruhr-Universität Bochum, Bochum, Germany.
Zeitschrift fur medizinische Physik
|June 16, 2023
概括
超声波定位显微镜 (ULM) 提供超高分辨率的微血管成像和流量测量,甚至在毛细血管水平. 这种技术利用微泡来增强可视化,从临床前使用到临床使用.
科学领域:
- 医疗成像医学成像
- 生物物理学的生物物理.
- 超声波技术 超声波技术 超声波技术
背景情况:
- 传统的超声波技术的衍射受限,阻碍了微血管的详细可视化.
- 像CEUS和多普勒这样的现有方法缺乏毛细血管级别的分辨率.
- 超声波定位显微镜 (ULM) 成为一种超高分辨率成像模式.
研究的目的:
- 解释ULM对于微血管成像的概念和适用性.
- 讨论ULM实施的处理步骤.
- 审查微血管结构重建和3D成像中的权衡.
主要方法:
- ULM以次像素精度定位单个微气泡 (MBs).
- 在图像序列中追踪MBs可以揭示血管形态和流动动力学.
- 使用商用,经过临床批准的对比剂.
主要成果:
- 超声波实现了超越传统超声波限制的分辨率.
- 允许成像和流量测量到毛细血管水平.
- 可以推导出微血管变化的定量参数.
结论:
- 在临床前和临床应用中,ULM具有显著的潜力.
- 应用包括研究血管生成,血管退化和器官功能.
- ULM促进了对微血管生理学和病理学的更深入的理解.
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