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重新审视的甘油三:高甘油三是心血管疾病中必要的治疗点吗?

Heinz Drexel¹, Juan Tamargo², Juan Carlos Kaski³

¹Vorarlberg Institute for Vascular Investigation and Treatment (VIVIT), Vorarlberg, Austria.

European heart journal. Cardiovascular pharmacotherapy

|June 16, 2023

概括

尽管降低了LDL-C,但动脉样硬化心血管疾病 (ASCVD) 的残留风险仍然存在. 高甘油 (TG) 是一个关键因素,特定的疗法显示出预防的希望.

科学领域:

心脏病学心脏病学
代谢障碍代谢障碍代谢障碍
药理学药理学是指药理学的学科.

背景情况:

尽管有效的低密度脂蛋白胆固醇 (LDL-C) 降低疗法,残留动脉样硬化心血管疾病 (ASCVD) 风险仍然是一个重大的临床挑战.
高血甘油三 (TG) 水平越来越被认为是ASCVD的独立风险因素或标志物.
了解高甘油三血症的病理生理学对于解决残留ASCVD风险至关重要.

研究的目的:

审查过高甘油三血症的病理生理学.
分析针对TG的治疗剂的作用机制.
解释相互矛盾的临床试验数据,并概述ASCVD在患有高甘油三血症的患者当前的预防策略.

主要方法:

流行病学研究和临床试验的文献综述.
对脂质调节疗法的机制数据的分析.
关于预防初级和二级心血管疾病 (CVD) 的证据综合.

主要成果:

纤维素可以通过降低TG和增加高密度脂蛋白胆固醇 (HDL-C) 来提供初级预防的好处,可能会超过LDL-C的增加.
在二次心血管疾病预防中,处方omega-3脂肪酸 (icosapent ethyl) 与他类药物相结合显示出有前途.
当前的治疗策略需要仔细考虑个体患者的个人资料和风险因素.

结论:

过高甘油三血是减少残留ASCVD风险的关键目标.
特定的药理干预措施,如纤维酸和纯化的EPA,在不同的临床环境中显示出希望.
对管理高TG水平的新策略进行进一步的研究是有必要的,以改善心血管结果.

关键词:

动脉样硬化是一种动脉样硬化.心血管疾病是什么心血管疾病过高甘油三血症的高血糖三血症降脂疗法是一种降脂疗法.脂质蛋白是一种脂质蛋白.类他类药物是一种药物.

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