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Updated: Jul 26, 2025

A Standard Methodology to Examine On-site Mutagenicity As a Function of Point Mutation Repair Catalyzed by CRISPR/Cas9 and SsODN in Human Cells
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分子编辑增强了针对menaquinone的抗生素Lysocin E和WAP-8294A2的氧化抵抗

Junhao Fu1, Yosuke Nakata1, Hiroaki Itoh1

  • 1Graduate School of Pharmaceutical Sciences, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-0033, Japan.

Chemistry (Weinheim an der Bergstrasse, Germany)
|June 16, 2023
PubMed
概括

莱索辛E和WAP-8294A2通过破坏细菌膜,表现出强大的抗菌活性. 用纳夫他林取代他们的内醇环,提高了氧化抵抗力,同时保持了抗菌功效,提供了新的药物开发策略.

关键词:
抗生素 抗生素是一种抗生素.宏观循环是一个宏观循环.酸是一种酸.有活性氧物种的反应性氧物种.结构 - 活动关系结构 - 活动关系

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