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多价双循环是一种有效的抗病毒方式,可以有效抑制SARS-CoV-2
Katherine U Gaynor1, Marina Vaysburd2, Maximilian A J Harman1
1Bicycle Therapeutics, Portway Building, Granta Park, Cambridge, CB21 6GS, United Kingdom.
Nature communications
|June 16, 2023
概括
研究人员使用自行车开发了一种新型抗病毒疗法,自行车是受限制的. 这些自行车有效地抑制了SARS-CoV-2变种,并减少了动物模型中的病毒载量,为抗击不断演变的病毒提供了新的策略.
科学领域:
- 药物发现和开发 药物发现和开发
- 病毒学 病毒学
- 生物化学 生物化学
背景情况:
- 随着COVID-19的流行,人们越来越需要新的治疗方法,而不是抗体和小分子.
- 现有治疗方法面临的挑战是新出现的SARS-CoV-2关注变种 (VoC).
研究的目的:
- 引入和评估自行车作为针对SARS-CoV-2的第三种抗病毒方式.
- 为了证明自行车对多种SARS-CoV-2变体和临床前模型的有效性.
主要方法:
- 查菌体库以识别SARS-CoV-2尖端蛋白结合剂.
- 对已识别的结合剂进行化学修饰,以制造多重化和双相性单车剂.
- 在hACE2-转基因小鼠和叙利亚黄金仓鼠体内测试,以评估抗病毒活性和宿主反应.
主要成果:
- 识别针对SARS-CoV-2尖刺蛋白的独特自行车结合剂.
- 通过多元化将初始微分子结合剂转化为强大的纳米分子抑制剂.
- 开发对多种VoC有效的双类毒剂,包括Alpha,Beta,Delta和Omicron.
- 在动物模型中,证明了病毒性血症的减少和宿主炎症的预防.
结论:
- 自行车代表了一种有前途的新型抗病毒方式,具有类似药物的特性.
- 自行车的化学组合性允许强大的抑制和广泛向病毒变体.
- 自行车疗法显示出对抗当前和未来快速发展的病毒威胁的潜力.
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