SARS-CoV-2对甲状腺的潜在影响:目前的进展和趋势
Avaniyapuram Kannan Murugan1, Ali S Alzahrani2,3
1Division of Molecular Endocrinology, Department of Molecular Oncology, King Faisal Specialist Hospital and Research Centre, Riyadh, 11211, Saudi Arabia. akmurugan@gmail.com.
Endocrine
|June 16, 2023
概括
严重急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 可以导致甲状腺上腺功能障碍,如甲状腺功能低下症和低血症. 这篇评论探讨了SARS-CoV-2的情况.
科学领域:
- 内分泌学 在内分泌学.
- 病毒学 病毒学
- 病理学 病理学 病理学
背景情况:
- 严重急性呼吸系统综合征-冠状病毒-2 (SARS-CoV-2) 感染会影响多个器官,包括内分泌腺.
- 病毒利用ACE2受体和相关蛋白质 (TMPRSS2,furin,NRP1,NRP2) 进入细胞.
- 新出现的证据将SARS-CoV-2与副甲状腺功能障碍联系起来,特别是副甲状腺功能障碍和低血症.
研究的目的:
- 审查目前对SARS-CoV-2在甲状腺疾病中的作用的理解.
- 为了研究副甲状腺腺感染的机制由SARS-CoV-2.
- 为了探索COVID-19中的副甲状腺功能障碍,COVID-19后的情况,以及接种疫苗的病例.
主要方法:
- 实验和临床研究的综合文献综述.
- 在甲状腺细胞中分析涉及ACE2,TMPRSS2,furin,NRP1和NRP2的分子机制.
- 讨论临床表现和对甲状腺功能潜在的长期影响.
主要成果:
- SARS-CoV-2 感染与各种副甲状腺疾病有关,包括副甲状腺功能低下和低血症.
- 甲状腺细胞表达的分子 (ACE2,TMPRSS2,furin,NRP1,NRP2) 便于病毒进入.
- 讨论了COVID-19,后COVID-19和疫苗相关病例中副甲状腺功能障碍的潜在机制.
结论:
- 感染SARS-CoV-2感染对患上副甲状腺功能障碍的风险很大.
- 了解病变的产生对于有效管理副甲状腺并发症至关重要.
- 需要进一步的研究来阐明长期COVID-19的影响,并优化COVID-19后的甲状腺关节护理.
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