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上升性大动脉扩张与硬心血管事件有关,这是多中心ARGO-Perspective项目后续的结果
Lorenzo Airale1, Francesco Borrelli1, Alessio Arrivi2
1Department of Medical Sciences, Hypertension Center-University of Torino-AOU Città della Salute e della Scienza di Torino, Torino, Italy.
概括
大动脉根扩张与高血压患者发生重大心血管不良事件的风险更高有关. 这一发现强调了大动脉扩张是心血管结果的重要预测因素,即使考虑到其他危险因素.
科学领域:
- 心脏病学 心脏病学
- 高血压研究 高血压研究
- 血管医学 血管医学
背景情况:
- 大动脉根扩张是一种潜在的高血压介导器官损伤 (HMOD).
- 之前关于大动脉根扩张作为HMOD的研究是异质的,缺乏对其作用的清晰度.
- 基本高血压带来显著的心血管风险,需要识别所有HMODs.
研究的目的:
- 调查大动脉根扩张 (AAD) 和主要不良心血管事件 (MACE) 之间的关联.
- 为了确定AAD是否是MACE的独立预测因子在患有基本高血压的患者中.
- 澄清AD作为潜在的HMOD的作用.
主要方法:
- 从六家意大利医院招募了445名高血压患者的队列 (ARGO-SIIA研究).
- 患者的随访时间平均为60个月,数据通过电话和医院记录收集.
- 大动脉扩张的定义是使用性别特定的值 (男性41毫米,女性36毫米).
主要成果:
- AAD与MACE发生率的增加显著相关 (HR=4.07,p<0.001).
- 在调整年龄,性别和身体表面积 (HR=2.91,p=0.020) 之后,这种关联仍然显著.
- AAD是MACE的独立预测因子,即使对已确定的HMOD进行校正,如左心房扩大和左心室缩 (HR=2.43,p=0.045).
结论:
- 上升的大动脉扩张与高血压患者的MACE风险大幅增加有关.
- AAD应被认为是基本高血压中心血管事件的重要预测因素.
- 识别和管理大动脉根扩张可能对于预防高血压患者心血管并发症至关重要.
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