在早产婴儿中与急性损伤相关的因素 服用万科米:一项回顾性队列研究
Baek Sup Shin1, Seung Han Shin2, Seul Gi Park1
1Department of Pediatrics, Seoul National University Children's Hospital, Seoul National University College of Medicine, 101, Daehak-Ro, Jongno-Gu, Seoul, 03080, Republic of Korea.
BMC pediatrics
|June 16, 2023
概括
在早产婴儿中,将piperacillin-tazobactam与vancomycin结合使用并没有增加急性损伤风险. 在这个人群中,较低的妊娠年龄和死性肠球炎与损伤有关.
科学领域:
- 新生儿医学 新生儿医学
- 药理学 药理学是指药理学的学科.
- 腎臟病學 (nephrology) 是一種醫學.
背景情况:
- 香草素 (VCM) 对于阳性感染至关重要,但具有毒性风险.
- 皮佩拉西林-塔扎巴克坦 (TZP) 可能会使老年患者的VCM诱导的毒性恶化.
- 关于TZP和VCM对新生儿功能综合作用的数据有限.
研究的目的:
- 为了确定与VCM同时使用TZP是否会增加早产婴儿急性损伤 (AKI) 风险.
- 为了确定与VCM治疗的早产婴儿中AKI相关的因素.
主要方法:
- 对早产婴儿 (出生体重小于1500克) 接受VCM治疗3天以上的回顾性研究.
- 由血清肌素增加 (≥0.3 mg/dL或≥1.5x基线) 定义的AKI.
- 在VCM+TZP和仅VCM组之间比较AKI发病率和相关因素.
主要成果:
- 在VCM+TZP (n=25) 和仅VCM (n=28) 组之间,AKI发病率没有显著差异.
- 较低的妊娠年龄 (调整的OR:0.58) 和死性肠球炎 (调整的OR:37.65) 与AKI显著相关.
- 专利性动脉管道显示了与AKI相关的趋势 (调整后OR:5.23).
结论:
- 同时使用TZP并不会增加VCM的出生体重非常低的婴儿的AKI风险.
- 较低的妊娠年龄和死性肠球炎是这种脆弱人群中AKI的关键风险因素.
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