产前抗抑郁药暴露和情绪障碍直到22岁:丹麦登记研究报告
Mette Bliddal1,2, Rikke Wesselhoeft2,3, Katrine Strandberg-Larsen4
1Research unit OPEN, Department of Clinical Research, University of Southern Denmark, Odense, Denmark.
Child and adolescent psychiatry and mental health
|June 16, 2023
概括
怀孕期间选择性血清素再吸收抑制剂 (SSRI) 的使用与儿童患抑郁症和焦虑症的风险更高有关. 然而,这种关联也可能受到母亲的健康状况的影响.
科学领域:
- 精神病学和行为科学
- 临床流行病学 临床流行病学
- 药理学 药理学是指药理学的学科.
背景情况:
- 选择性血清素再吸收抑制剂 (SSRI) 是怀孕期间常见的抗抑郁药.
- 以前的研究表明,产前SSRI暴露与儿童抑郁和焦虑增加之间存在潜在联系,但因果关系仍然不确定.
研究的目的:
- 研究孕妇在怀孕期间使用SSRI与22岁以下儿童的心理健康结果之间的关联.
- 为了区分药物效应与潜在的混因素,如母亲的疾病严重程度.
主要方法:
- 对1997年至2015年间出生的1,094,202名丹麦儿童进行前性队列研究.
- 主要暴露:选择性血清素再吸收抑制剂 (SSRI) 处方在怀孕期间填充.
- 主要结局:首次诊断出抑郁,焦虑或适应障碍,或处方抗抑郁药.
- 倾向性得分权重和丹麦国家出生队列数据被用于调整混因素.
主要成果:
- 与未暴露儿童相比,在子宫内暴露于SSRI的儿童的精神健康障碍率较高 (HR=1.55).
- 这些疾病的早期发病年龄在暴露于SSRI的儿童 (9岁) 和未暴露的儿童 (12岁) 中观察到.
- 父亲使用SSRI和母亲在怀孕后使用SSRI也与儿童心理健康风险增加有关.
结论:
- 产前SSRI暴露与儿童患精神健康障碍的风险增加有关.
- 观察到的风险可能部分归因于潜在的母亲疾病严重程度或其他混因素,需要仔细考虑.
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