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Updated: Jul 26, 2025

Targeted Plasma Membrane Delivery of a Hydrophobic Cargo Encapsulated in a Liquid Crystal Nanoparticle Carrier
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包装动态和激活非球形纳米粒子吸收的关键条件

Ke Xiao1, Rui Ma2, Chen-Xu Wu2

  • 1Wenzhou Institute, University of Chinese Academy of Sciences, Wenzhou 325016, People's Republic of China and Department of Physics, College of Physical Science and Technology, Xiamen University, Xiamen 361005, People's Republic of China.

Physical review. E
|June 17, 2023
PubMed
概括

这项研究揭示了非球形纳米粒子 (NP) 如何围绕细胞膜. 优化活性力,粘度,粘合力和膜张力可增强NP细胞吸收,用于药物输送应用.

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Factors Affecting Dissolution: Particle Size and Effective Surface Area01:23

Factors Affecting Dissolution: Particle Size and Effective Surface Area

Dissolution kinetics, an essential aspect of oral drug delivery, is significantly influenced by the drug's particle size. According to the Noyes-Whitney dissolution model, the dissolution rate correlates directly with the drug's surface area. The larger the surface area, the higher the drug's solubility in water, leading to a faster drug dissolution rate. Reducing particle size increases the effective surface area, enhancing the dissolution process. Micronization and nanosizing are...
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