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雌激素受体βrs1256049多态和前列腺癌风险之间的关联:元分析

Hassane Gazzaz¹, Mohammed El Feniche², Ahmed Ameur³

¹Clinical, metabolic and molecular biochemistry Team, Faculty of Medicine and Pharmacy, Mohammed V University, 10100 Rabat, Morocco, Higher Institute of Nursing Professions and Health Techniques of Marrakech, annex of Safi, Morocco.

Annales de biologie clinique

|June 17, 2023

概括

雌激素受体β (ESR-β) rs1256049多态性显示没有与前列腺癌 (PCa) 风险的总体关联. 然而,它可能会降低亚洲人的PCa风险,增加高加索人的风险.

科学领域:

遗传学遗传学是一个
在瘤学瘤学.
分子生物学分子生物学

背景情况:

雌激素受体β (ESR-β) 基因在前列腺组织中可能具有抑制作用.
ESR-β是前列腺癌 (PCa) 的潜在治疗点.
之前对ESR-β rs1256049多态性和PCa风险的研究已经产生了不一致的结果.

研究的目的:

进行一项元分析,评估ESR-β rs1256049多态和PCa敏感性之间的关联.
为了澄清先前调查的相互矛盾的结果.

主要方法:

在PubMed,Web of Science,ScienceDirect和Google Scholar的系统文献搜索2022年2月5日之前发表的研究.
11个病例控制研究的元分析,包括9390个PCa病例和10057个对照.
基于种族 (亚洲人和高加索人) 的子组分析.

主要成果:

在所有遗传模型中,总体的元分析显示ESR-β rs1256049多态和PCa风险之间没有显著的关联.
在亚组分析中,亚洲人在异胞 (OR=0.75) 和主导 (OR=0.80) 模型下显著降低PCa风险.
在基 (OR=1.17),异位 (OR=1.15) 和主导 (OR=1.17) 模型下,高加索人表现出显著增加的PCa风险.

结论:

总体而言,ESR-β rs1256049多态性似乎不是前列腺癌的重要危险因素.
这种多态性可能会在亚洲人群中对PCa产生保护作用.
相反,ESR-β rs1256049多态可能与高加索人群中PCa风险增加有关.

关键词:

这是ESR-β.这是一个元分析.多形态主义的多态主义.前列腺癌是前列腺癌.

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