在抗mGluR5脑炎的临床特征和脑MRI体积变化
Yueqian Sun1,2, James X Tao3, Xiong Han4
1Department of Neurology, Beijing Tiantan Hospital, Capital Medical University, Beijing, China.
Annals of clinical and translational neurology
|June 17, 2023
概括
抗甲基氨酸受体5 (mGluR5) 脑炎表现为认知缺陷,行为变化和发作. 杏仁体在MRI上的扩大是关键特征,大多数患者恢复良好.
科学领域:
- 神经学 神经学
- 免疫学 免疫学 免疫学
- 神经科学是一个神经科学.
背景情况:
- 抗甲基氨酸受体5 (mGluR5) 脑炎是一种罕见的自身免疫神经系统疾病.
- 它经常被忽视,因此需要进一步描述其临床和神经影像资料.
研究的目的:
- 描述抗mGluR5脑炎的临床表现.
- 识别与疾病相关的独特的神经成像特征,包括体积变化.
主要方法:
- 对29名抗mGluR5脑炎患者的回顾性分析 (15名新患者,14名先前报告).
- 临床特征被系统地记录下来.
- 使用FreeSurfer进行的脑MRI体积分析对9名新患者进行,并与早期和慢性阶段的25名健康对照进行了比较.
主要成果:
- 常见的症状包括认知缺陷 (72.4%),行为/情绪障碍 (69%),发作 (55.2%) 和睡眠障碍 (44.8%).
- 在75.9%的患者中,MRI揭示了T2/FLAIR超强度在半角及皮下区域.
- 与对照组相比,在早期和慢性阶段都观察到显著的杏仁体扩大 (P < 0.001).
- 在7名患者中发现了瘤.
结论:
- 认知障碍,行为障碍,发作和睡眠障碍是突出的临床特征.
- 抗mGluR5脑炎的预后一般很好,大多数患者完全康复,即使在副瘤病例中也是如此.
- 杏仁体扩大代表了一个独特的MRI发现,对了解疾病过程有潜在的影响.
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