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低脂肪乳制品消费和肺癌风险:一项大型前性队列研究
Zhiyong Zhu1, Linglong Peng1, He Zhou2,3
1Department of Gastrointestinal Surgery, The Second Affiliated Hospital of Chongqing Medical University, Chongqing, China.
Cancer medicine
|June 17, 2023
概括
消费低脂肪乳制品与患肺癌的风险降低有关. 这表明,增加这些食物的摄入量可能有助于预防肺癌.
科学领域:
- 流行病学 流行病学
- 营养科学 营养科学
- 在瘤学瘤学.
背景情况:
- 关于低脂肪乳制品摄入量与肺癌风险之间的关系,流行病学证据有限.
- 乳制品在癌症发展或预防中的作用正在研究中.
- 这项研究解决了关于低脂肪乳制品和肺癌的知识差距.
研究的目的:
- 研究低脂肪乳制品消费与肺癌风险之间的关联.
- 为了确定增加低脂肪乳制品摄入量是否与较低的肺癌发病率有关.
- 提供有关乳制品和预防肺癌的流行病学证据.
主要方法:
- 利用前列腺,肺,结肠直肠和卵巢 (PLCO) 癌症查试验的数据.
- 采用Cox的比例风险模型来评估低脂肪乳制品摄入量与肺癌之间的联系.
- 进行了子组和灵敏度分析,以验证发现并确定效果修饰剂.
主要成果:
- 总共有98,459名参与者被纳入,观察到1642例肺癌病例.
- 低脂肪乳制品消费的高四分位数与肺癌风险显著降低有关 (HR:0.769).
- 在低脂肪乳制品摄入量和肺癌风险之间观察到一个反向的,非线性剂量反应关系.
结论:
- 增加低脂肪乳制品的消费与肺癌风险降低有显著关联.
- 研究结果表明,加入更多的低脂乳制品可能是预防肺癌的策略.
- 进一步的研究可以探索这种保护性关联背后的机制.
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