在寻求不育治疗的妇女中,与卵巢储备相关的铁摄入量
N Jiménez-Cardozo1,2, M Mitsunami3, L Mínguez-Alarcón4,5
1Grupo de Investigación en Ciencias Básicas y Clínicas de la Salud, Pontificia Universidad Javeriana, Cali, Colombia.
Human reproduction (Oxford, England)
|June 17, 2023
概括
高补充铁摄入量与接受生育治疗的妇女的卵巢储量减少有关. 摄入45毫克/天或更多补充铁的女性表现出较低的 antral 毛囊数量和较高的 FSH 水平,表明对生育能力的潜在影响.
科学领域:
- 生殖内分泌学 生殖内分泌学
- 环境健康 环境健康
- 不孕症研究 不孕症研究
背景情况:
- 关于铁摄入量和卵巢储备的现有文献有限且不一致.
- 一些证据表明,铁的潜在性腺毒性作用.
研究的目的:
- 研究寻求生育护理的妇女的铁摄入量和卵巢储备之间的关联.
- 为了确定补充铁的摄入是否会影响卵巢储备的标志物.
主要方法:
- 在一个生育中心对582名妇女的观察研究.
- 铁的摄入量通过食物频率调查问卷进行评估.
- 卵巢储备通过腹膜卵泡计数 (AFC) 和第三天的FSH水平来衡量.
主要成果:
- 较高的补充铁摄入量 (≥45 mg/天) 与AFC相反相关.
- 摄入≥65毫克/天补充铁的女性与摄入≤20毫克/天的女性相比,AFC降低了32%.
- 更高的补充铁摄入量 (≥65毫克/天) 与更高的FSH水平有关.
结论:
- 在接受生育治疗的妇女中,每天超过45毫克的补充铁摄入量与卵巢储量减少有关.
- 需要进一步的研究来澄清剂量反应关系以及怀孕前补充铁的风险益处平衡.
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